Effectiveness of EGFR treatment is impaired through an early adaptive response. TNF–JNK–Axl–ERK signaling contributes to this primary resistance to EGFR inhibition and might serve as novel target to improve EGFR inhibition.

中文翻译：

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帮助抑制EGFR以阻止癌症

早期的适应性反应会削弱EGFR治疗的有效性。TNF–JNK–Axl–ERK信号传导有助于这种对EGFR抑制的主要抗性，并且可能作为改善EGFR抑制的新靶标。