Oligonucleotides containing internal triazole–3′-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5′-side of the triazole does not stabilise duplexes. Triazole–LNA confers great resistance towards enzymatic degradation relative to LNA alone.

中文翻译：

---

锁核酸（LNA）增强了三唑连接的DNA对RNA的结合亲和力

含有内部三唑–3'-LNA连接的寡核苷酸以与未修饰寡核苷酸相似的亲和力和特异性与互补RNA结合，并且比仅含有三唑的寡核苷酸要好得多。相反，三唑的5'侧的LNA不能稳定双链体。相对于单独的LNA，三唑-LNA赋予了对酶促降解的强大抵抗力。