Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89,Chemical Communications

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Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89
Chemical Communications ( IF 4.9 ) Pub Date : 2017-07-12 00:00:00 , DOI: 10.1039/c7cc03572a
L. Allott _{1,

2,

3,

4} , C. Da Pieve _{1,

2,

3,

4} , J. Meyers _{2,

3,

4,

5,

6} , T. Spinks _{1,

2,

3,

4} , D. M. Ciobota _{1,

2,

3,

4} , G. Kramer-Marek _{1,

2,

3,

4} , G. Smith _{1,

2,

3,

4}

Affiliation

The future of ⁸⁹Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for ⁸⁹Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with ⁸⁹Zr. This work broadens the selection of available chelators for ⁸⁹Zr in search of improved successors to DFO for clinical ⁸⁹Zr-immuno-PET.

中文翻译：

DFO-HOPO作为89锆八齿螯合剂的评估

⁸⁹ Zr基免疫PET的未来取决于与目前使用的去铁胺（DFO）相比具有更高稳定性的新型螯合剂的开发。在本文中，我们报告了八齿分子DFO-HOPO（3）的评估，该分子是⁸⁹ Zr的合适螯合剂，是DFO的更稳定替代物。该分子在基于DFO-HOPO的双功能螯合剂（BFC）的未来开发中具有良好的潜力，该双功能螯合剂可对⁸⁹ Zr的生物分子进行放射性标记。这项工作拓宽了⁸⁹ Zr可用螯合剂的选择范围，以寻找DFO用于临床⁸⁹ Zr-immuno-PET的改良后继剂。

更新日期：2017-07-28

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