Neural modulation technology and the capability to affect organ function have spawned the new field of bioelectronic medicine. Therapeutic interventions depend on wireless bioelectronic neural interfaces that can conformally and easily attach to small (few hundred micrometers) nerves located deep in the body without neural damage. Besides size, factors like flexibility and compliance to attach and adapt to visceral nerves associated moving organs are of paramount importance and have not been previously addressed. This study proposes a novel flexible neural clip (FNC) that can be used to interface with a variety of different peripheral nerves. To illustrate the flexibility of the design, this study stimulates the pelvic nerve, the vagus nerve, and branches of the sciatic nerve and evaluates the feasibility of the design in modulating the function of each of these nerves. It is found that this FNC allows fine‐tuning of physiological processes such as micturition, heart rate, and muscle contractions. Furthermore, this study also tests the ability of wirelessly powered FNC to enable remote modulation of visceral pelvic nerves located deep in the body. These results show that the FNC can be used with a range of different nerves, providing one of the critical pieces in the field of bioelectronics medicines.

中文翻译：

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迈向生物电子医学—使用柔性神经夹对小周围神经进行神经调节

神经调节技术和影响器官功能的能力催生了生物电子医学的新领域。治疗性干预措施依赖于无线生物电子神经接口，该接口可以顺应性地并容易地附着于位于体内深处的小神经（几百微米），而不会造成神经损伤。除了大小以外，诸如与附着和适应内脏神经相关的运动器官的柔韧性和顺应性等因素也是最重要的，而且以前没有得到解决。这项研究提出了一种新型的柔性神经夹（FNC），可用于与多种不同的周围神经对接。为了说明设计的灵活性，本研究刺激了骨盆神经，迷走神经，和坐骨神经的分支，并评估该设计在调节这些神经中每条神经功能方面的可行性。发现该FNC可以微调生理过程，例如排尿，心率和肌肉收缩。此外，这项研究还测试了无线FNC能够远程调节位于体内深处的内脏骨盆神经的能力。这些结果表明，FNC可以与多种不同的神经配合使用，提供了生物电子医学领域的关键部件之一。这项研究还测试了无线FNC能够远程调节位于体内深处的内脏骨盆神经的能力。这些结果表明，FNC可以与多种不同的神经配合使用，提供了生物电子医学领域的关键部件之一。这项研究还测试了无线FNC能够远程调节位于体内深处的内脏骨盆神经的能力。这些结果表明，FNC可以与多种不同的神经配合使用，提供了生物电子医学领域的关键部件之一。