A combination of ‘orthogonal’ thiol–ene ‘click’ reactions is utilized for fabrication and functionalization of micro-patterned hydrogels. A furan-protected maleimide-containing parent copolymer is partially activated via the retro Diels–Alder reaction to obtain an ‘orthogonally’ functionalizable copolymer, where the different functional groups can be exploited for multi-functionalization or fabrication of functional hydrogels using combination of the nucleophilic and radical thiol–ene reactions.

中文翻译：

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正交硫醇-烯“点击”反应：图案化水凝胶的制备和功能化的强大组合

“正交”硫醇-烯“点击”反应的组合被用于微模式水凝胶的制备和功能化。呋喃保护的含顺丁烯二酰亚胺的母体共聚物通过逆Diels-Alder反应部分活化，得到“正交”可官能化的共聚物，其中不同的官能团可通过亲核试剂的结合用于功能化水凝胶的多功能化或制备和自由基硫醇-烯反应。