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Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides
Chemical Communications ( IF 4.9 ) Pub Date : 2017-07-06 00:00:00 , DOI: 10.1039/c7cc05025a
Iman Kavianinia 1, 2, 3, 4, 5 , Sung-Hyun Yang 1, 2, 3, 4, 5 , Harveen Kaur 1, 2, 3, 4, 5 , Paul W. R. Harris 1, 2, 3, 4, 5 , Renwick C. J. Dobson 2, 5, 6, 7, 8 , Antony J. Fairbanks 5, 9, 10, 11 , Margaret A. Brimble 1, 2, 3, 4, 5
Affiliation  

Advanced lipid peroxidation end-products (ALEs) accumulate with ageing and oxidative stress-related diseases. Despite their potential therapeutic value, there are no suitably protected ALE building blocks reported in the literature to enable their site-specific incorporation into synthetic peptides. The synthesis of an Fmoc-protected ALE building block, N-(3-methylpyridinium)lysine (MP-lysine) and its incorporation into collagen model peptides is reported.

中文翻译:

合成和将先进的脂质过氧化终产物构建单元并入胶原模拟肽

晚期脂质过氧化终产物(ALE)会随着衰老和氧化应激相关疾病而积累。尽管它们具有潜在的治疗价值,但文献中没有报道适当保护的ALE结构单元能够将其位点特异性掺入合成肽中。的Fmoc-保护的ALE建筑砌块,合成Ñ 报道(3-甲基吡啶鎓)赖氨酸(MP-赖氨酸)和其掺入到胶原模型肽- 。
更新日期:2017-07-26
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