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D-mannose induces regulatory T cells and suppresses immunopathology.
Nature Medicine ( IF 82.9 ) Pub Date : 2017-Sep-01 , DOI: 10.1038/nm.4375
Dunfang Zhang , Cheryl Chia , Xue Jiao , Wenwen Jin , Shimpei Kasagi , Ruiqing Wu , Joanne E Konkel , Hiroko Nakatsukasa , Peter Zanvit , Nathan Goldberg , Qianming Chen , Lingyun Sun , Zi-Jiang Chen , WanJun Chen

D-mannose, a C-2 epimer of glucose, exists naturally in many plants and fruits, and is found in human blood at concentrations less than one-fiftieth of that of glucose. However, although the roles of glucose in T cell metabolism, diabetes and obesity are well characterized, the function of D-mannose in T cell immune responses remains unknown. Here we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation, and increased the proportion of Foxp3+ regulatory T cells (Treg cells) in mice. In vitro, D-mannose stimulated Treg cell differentiation in human and mouse cells by promoting TGF-β activation, which in turn was mediated by upregulation of integrin αvβ8 and reactive oxygen species generated by increased fatty acid oxidation. This previously unrecognized immunoregulatory function of D-mannose may have clinical applications for immunopathology.

中文翻译:

D-甘露糖诱导调节性T细胞并抑制免疫病理。

D-甘露糖是葡萄糖的C-2差向异构体,天然存在于许多植物和水果中,并且在人血中的浓度不到葡萄糖的五十分之一。然而,尽管葡萄糖在T细胞代谢,糖尿病和肥胖中的作用已被很好地表征,但是D-甘露糖在T细胞免疫应答中的功能仍然未知。在这里,我们显示通过饮用水补充可以安全地实现的D-甘露糖的超生理水平抑制了自身免疫性糖尿病和气道炎症的小鼠模型的免疫病理,并增加了Foxp3 +调节性T细胞(T reg细胞)的比例。在体外,D-甘露糖刺激的T reg通过促进TGF-β活化,这继而又被的整合素α上调介导的在人类和小鼠细胞细胞分化v β 8个通过增加的脂肪酸氧化产生和活性氧。D-甘露糖的这种先前无法识别的免疫调节功能可能在免疫病理学中具有临床应用。
更新日期:2017-09-07
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