The feasibility of performing an ortho-lithiation reaction in a T-reactor and a spinning disc reactor (SDR) at ambient temperature has been demonstrated and compared experimentally to a conventional batch stirred tank reactor (STR) process performed at a cryogenic temperature of −70 °C. The benefits of significantly improved mixing and much shorter residence times in the flow reactors eliminated the need for cryogenic cooling in batch processing which is a costly requirement. A theoretical evaluation of a scaled up process with a design product output of 3 tons per year highlights that significant process intensification is achievable in the flow reactors which demonstrate higher energy efficiency, better volume efficiency, smaller processing inventory, and smaller equipment footprint. For this reaction, the performance of the T-reactor is the best among the three reactors leading to much lower reactor investment and operating cost. The SDR was also demonstrated to be effective, even though this reaction did not take advantage of its inherent capabilities in solid handling or rapid heat removal through evaporation/gas disengagement, all of which present major challenges in enclosed channel geometries such as the T-reactor.

中文翻译：

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在环境条件下强化连续邻位锂化工艺的过程-对可持续性利益的理解和评估

已经证明了在室温下在T反应器和旋转盘式反应器（SDR）中进行邻位锂化反应的可行性，并将其与在-70的低温下进行的常规间歇搅拌釜反应器（STR）工艺进行了实验比较。 ℃。显着改善的混合效果和在流动反应器中缩短停留时间的好处消除了批量处理中对低温冷却的需求，这是一项昂贵的要求。对每年设计产品产量为3吨的按比例放大工艺的理论评估突出表明，在流动反应器中可以实现显着的工艺强化，这显示出更高的能源效率，更好的体积效率，更小的加工库存和更小的设备占地面积。对于这个反应，T型反应器的性能在这三个反应堆中是最好的，从而大大降低了反应堆的投资和运行成本。SDR也被证明是有效的，即使该反应没有利用其固有的固体处理能力或通过蒸发/气体分离快速除热的能力，所有这些都对密闭通道的几何形状（例如T型反应器）提出了重大挑战。