Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.

中文翻译：

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针叶树醛共轭双键对于热休克因子1介导的细胞保护至关重要

松柏基醛（1）以前被报道为热休克因子1（HSF1）的有效诱导剂。在这里，我们进一步研究的活性药效1使用衍生物松柏醇（HSF1激活2），4-羟基-3- methoxyphenylpropanal（3）和4-羟基-3- methoxyphenylpropanol（4）。既1和2导致增加的存活天数致死辐射（IR）剂量后。在小鼠中，IR引起的骨髓（BM）细胞数量和Ki67阳性BM细胞减少也明显恢复了1或2。这些结果表明1和2的乙烯基部分 诱导HSF1是必需的，HSF1可能用于开发小分子，以保护正常细胞免受细胞毒性药物和放射线的损害。