Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.

中文翻译：

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超越生长信号：Paneth细胞在代谢上支持ISC。

单个Lgr5肠干细胞（ISC）可以在体外扩增为上皮类器官或“小肠”，它们是自我组织的细胞结构，可重新构建肠道分化程序。构成肠道干细胞生态位的Paneth细胞分泌干细胞生长信号，因此对于该过程至关重要。Rodríguez-Colman等人在《自然》杂志上发表的最新论文中。描述Paneth细胞如何支持ISC的代谢状态。