Enantioselective synthesis of pyrrole-annulated medium-sized-ring compounds by an iridium-catalyzed allylic dearomatization/retro-Mannich/hydrolysis sequence is presented. Various substituted pyrrole-annulated seven- and eight-membered-ring products were obtained under mild reaction conditions with moderate to good yields and excellent enantioselectivity. Additionally, these products contain a scaffold widely distributed in natural products and biologically active compounds. The current method provides a convenient way for accessing such pyrrole-anuulated medium-sized-ring compounds.

中文翻译：

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铱催化的吡咯修饰的中环环化合物的对映选择性合成

提出了通过铱催化的烯丙基芳烃脱芳香化/复古曼尼希/水解顺序对吡咯环化的中型环化合物的对映选择性合成。在温和的反应条件下以中等至良好的收率和优异的对映选择性获得了各种取代的吡咯环化的七元和八元环产物。另外，这些产品包含广泛分布于天然产物和生物活性化合物中的支架。当前的方法提供了一种方便的方式来获取此类吡咯-环氧基的中型环化合物。