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The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus [Reviews]
Clinical Microbiology Reviews ( IF 36.8 ) Pub Date : 2017-07-19 00:00:00 , DOI: 10.1128/cmr.00120-16
Elisabeth Hodille 1 , Warren Rose 2 , Binh An Diep 3 , Sylvain Goutelle 4 , Gerard Lina 1 , Oana Dumitrescu 1
Affiliation  

Staphylococcus aureus is often involved in severe infections, in which the effects of bacterial virulence factors have great importance. Antistaphylococcal regimens should take into account the different effects of antibacterial agents on the expression of virulence factors and on the host's immune response. A PubMed literature search was performed to select relevant articles on the effects of antibiotics on staphylococcal toxin production and on the host immune response. Information was sorted according to the methods used for data acquisition (bacterial strains, growth models, and antibiotic concentrations) and the assays used for readout generation. The reported mechanisms underlying S. aureus virulence modulation by antibiotics were reviewed. The relevance of in vitro observations is discussed in relation to animal model data and to clinical evidence extracted from case reports and recommendations on the management of toxin-related staphylococcal diseases. Most in vitro data point to a decreased level of virulence expression upon treatment with ribosomally active antibiotics (linezolid and clindamycin), while cell wall-active antibiotics (beta-lactams) mainly increase exotoxin production. In vivo studies confirmed the suppressive effect of clindamycin and linezolid on virulence expression, supporting their utilization as a valuable management strategy to improve patient outcomes in cases of toxin-associated staphylococcal disease.

中文翻译:

抗生素在金黄色葡萄球菌致病性调节中的作用[综述]

金黄色葡萄球菌经常参与严重的感染,其中细菌毒力因子的作用非常重要。抗葡萄球菌方案应考虑到抗菌剂对毒力因子表达和宿主免疫反应的不同影响。进行PubMed文献搜索以选择有关抗生素对葡萄球菌毒素产生和宿主免疫反应的影响的相关文章。根据用于数据采集的方法(细菌菌株,生长模型和抗生素浓度)以及用于产生读数的测定对信息进行分类。回顾了报道的抗生素对金黄色葡萄球菌毒力调节的潜在机制。体外的相关性讨论了有关动物模型数据和从病例报告中提取的临床证据以及有关毒素相关葡萄球菌疾病管理的建议的观察结果。多数体外数据表明,用核糖体活性抗生素(利奈唑胺和克林霉素)治疗后毒力表达水平降低,而细胞壁活性抗生素(β-内酰胺类)主要增加外毒素的产生。体内研究证实了克林霉素和利奈唑胺对毒力表达的抑制作用,支持了它们作为有价值的管理策略,以改善毒素相关葡萄球菌病患者的预后。
更新日期:2017-07-20
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