Cyclic peptides can bind to protein targets with high affinities and selectivities, which makes them an attractive modality for the development of research reagents and therapeutics. Additional properties, including low inherent toxicity, efficient chemical synthesis, and facile modification with labels or immobilization reagents, increase their attractiveness. Cyclic peptide ligands against a wide range of protein targets have been isolated from natural sources such as bacteria, fungi, plants, and animals. Many of them are currently used as research tools, and several have found application as therapeutics, such as the peptide hormones oxytocin and vasopressin and the antibiotics vancomycin and daptomycin, proving the utility of cyclic peptides in research and medicine.

中文翻译：

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用于研究和药物开发的环肽的噬菌体选择

环肽可以以高亲和力和选择性与蛋白质靶标结合，这使其成为研究试剂和治疗剂开发的诱人方式。其他特性，包括低固有毒性，有效的化学合成以及使用标记物或固定化试剂的便捷修饰，均增加了它们的吸引力。已经从诸如细菌，真菌，植物和动物的天然来源中分离出了针对多种蛋白质靶标的环肽配体。它们中的许多目前被用作研究工具，并且发现了一些用于治疗的应用，例如催产素和血管加压素等肽激素以及万古霉素和达托霉素抗生素，证明了环状肽在研究和医学中的实用性。