One of the most important endogenous estrogens is 17β-estradiol, which disturbed the endocrine system, and causing adverse effects on the growth, reproduction and development of the body. It is necessary to develop a convenient and rapid analytical method to detect estradiol with high sensitivity and selectivity. For determination of 17β-estradiol, methods such as high performance liquid chromatography/mass spectrometry and gas chromatography/mass spectrometry were used. However, these methods often need expensive instruments, complex pretreatment, large volumes of harmful solvents and professional operation. Aptamers have been used as a new biosensor platform for detection of 17β-estradiol in different samples. This article provides an overview of the applications of aptasensors in analysis and monitoring of 17β-estradiol. After a brief description of the steroids, recent advances and applications of aptamer-based biosensors are presented. We have paid attention to the potential role of bioaffinity systems in the detection and quantitative determination of 17β-estradiol.

中文翻译：

---

基于纳米材料的Aptasensors和生物亲和力传感器可定量检测17β-雌二醇

最重要的内源性雌激素之一是17β-雌二醇，它会干扰内分泌系统，并对人体的生长，繁殖和发育产生不利影响。有必要开发一种方便，快速的分析方法，以高灵敏度和高选择性检测雌二醇。为了测定17β-雌二醇，使用了诸如高效液相色谱/质谱和气相色谱/质谱的方法。但是，这些方法通常需要昂贵的仪器，复杂的预处理，大量有害溶剂和专业操作。适体已被用作检测不同样品中17β-雌二醇的新生物传感器平台。本文概述了适体传感器在17β-雌二醇分析和监测中的应用。在简要介绍了类固醇之后，介绍了基于适体的生物传感器的最新进展和应用。我们已经关注了生物亲和系统在17β-雌二醇的检测和定量测定中的潜在作用。