Recent advances in transition metal-catalyzed C–H bond functionalization have profoundly impacted synthetic strategy. Since organic substrates typically contain several chemically distinct C–H bonds, controlling the regioselectivity of C–H bond functionalization is imperative to harness its full potential. Moreover, the ability to alter reaction pathways to selectively functionalize different C–H bonds in a substrate represents a greater opportunity and challenge. The choice of catalysts, ligands, solvents, and even more subtle variations of the reaction conditions have been shown to allow the formation of regioisomeric C–H functionalization products starting from the same precursors. This review describes recent advances in transition metal-catalyzed divergent C–H bond functionalization that highlight its potential in organic synthesis.

中文翻译：

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过渡金属催化的位点和区域发散的C–H键功能化

过渡金属催化的C–H键功能化的最新进展已深刻影响了合成策略。由于有机底物通常包含几个化学上不同的CH键，因此控制CH键功能化的区域选择性对于发挥其全部潜力势在必行。此外，改变反应途径以选择性功能化底物中不同C–H键的能力代表了更大的机遇和挑战。催化剂，配体，溶剂的选择，以及反应条件的更细微变化都被证明可以从相同的前体开始形成区域异构的CHH功能化产物。这篇综述描述了过渡金属催化的发散CH键功能化的最新进展，突出了其在有机合成中的潜力。