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Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells.
Nature Medicine ( IF 82.9 ) Pub Date : 2017-Aug-01 , DOI: 10.1038/nm.4373
Simon Rauber 1 , Markus Luber 1 , Stefanie Weber 1 , Lisa Maul 1 , Alina Soare 1 , Thomas Wohlfahrt 1 , Neng-Yu Lin 1 , Katharina Dietel 1 , Aline Bozec 1 , Martin Herrmann 1 , Mark H Kaplan 2 , Benno Weigmann 3 , Mario M Zaiss 1 , Ursula Fearon 4 , Douglas J Veale 5 , Juan D Cañete 6 , Oliver Distler 7 , Felice Rivellese 8 , Costantino Pitzalis 8 , Markus F Neurath 3 , Andrew N J McKenzie 9 , Stefan Wirtz 3 , Georg Schett 1 , Jörg H W Distler 1 , Andreas Ramming 1
Affiliation  

Inflammatory diseases such as arthritis are chronic conditions that fail to resolve spontaneously. While the cytokine and cellular pathways triggering arthritis are well defined, those responsible for the resolution of inflammation are incompletely characterized. Here we identified interleukin (IL)-9-producing type 2 innate lymphoid cells (ILC2s) as the mediators of a molecular and cellular pathway that orchestrates the resolution of chronic inflammation. In mice, the absence of IL-9 impaired ILC2 proliferation and activation of regulatory T (Treg) cells, and resulted in chronic arthritis with excessive cartilage destruction and bone loss. In contrast, treatment with IL-9 promoted ILC2-dependent Treg activation and effectively induced resolution of inflammation and protection of bone. Patients with rheumatoid arthritis in remission exhibited high numbers of IL-9+ ILC2s in joints and the circulation. Hence, fostering IL-9-mediated ILC2 activation may offer a novel therapeutic approach inducing resolution of inflammation rather than suppression of inflammatory responses.

中文翻译:

通过产生白细胞介素 9 的 2 型先天性淋巴细胞消退炎症。

关节炎等炎症性疾病是无法自发消退的慢性疾病。虽然触发关节炎的细胞因子和细胞途径已明确定义,但负责消退炎症的那些尚未完全表征。在这里,我们将产生白细胞介素 (IL)-9 的 2 型先天淋巴细胞 (ILC2s) 确定为协调慢性炎症消退的分子和细胞途径的介质。在小鼠中,IL-9 的缺乏会损害 ILC2 的增殖和调节性 T (T reg ) 细胞的活化,并导致慢性关节炎,伴有过度的软骨破坏和骨质流失。相比之下,用 IL-9 治疗促进了 ILC2 依赖性 T reg激活并有效诱导炎症消退和保护骨骼。缓解期的类风湿性关节炎患者在关节和循环系统中表现出大量的 IL-9 + ILC2。因此,促进 IL-9 介导的 ILC2 活化可能提供一种新的治疗方法,诱导炎症消退而不是抑制炎症反应。
更新日期:2017-09-07
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