The selective tumor- and bacteria-killing property is promising for biomedical implants in directly contact with tumor tissue but still presents a considerable challenge. In this study, a butyrate-inserted Ni–Ti layered double hydroxide film (LDH/Butyrate) is prepared on the surface of nitinol alloy via a simple hydrothermal treatment. The prepared film can selectively inhibit tumor growth and metastasis and bacterial infection by taking advantage of the overproduced H 2 O 2 in tumor and infection microenvironments: the pro-tumor and pro-infection molecule H 2 O 2 can be consumed by LDH/Butyrate, and cytotoxic butyrate inserted in LDH/Butyrate is subsequently exchanged out. Such a novel endogenous stimuli-responsive platform is expected to prevent tumor overgrowth, metastasis and bacterial infection and will find a promising application in the design of localized drug-eluting systems.

中文翻译：

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丁酸盐插入的 Ni-Ti 层状双氢氧化物膜用于 H 2 O 2 介导的肿瘤和细菌杀灭

选择性杀灭肿瘤和细菌的特性对于与肿瘤组织直接接触的生物医学植入物很有希望，但仍然存在相当大的挑战。在这项研究中，通过简单的水热处理在镍钛诺合金表面制备了丁酸盐插入的 Ni-Ti 层状双氢氧化物膜（LDH/丁酸盐）。制备的薄膜可以利用肿瘤和感染微环境中过量产生的H 2 O 2 选择性抑制肿瘤生长和转移以及细菌感染：促肿瘤和促感染分子H 2 O 2 可以被LDH/丁酸盐消耗，插入LDH/丁酸盐中的细胞毒性丁酸盐随后被交换出去。这种新型内源性刺激反应平台有望防止肿瘤过度生长，