Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.

中文翻译：

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线粒体功能障碍和潜在的抗癌治疗

线粒体功能障碍（MDF）已被确定为各种疾病的重要因素，从神经系统疾病到心血管系统疾病和代谢综合征。在具有缺陷的DNA损伤反应（DDR）机制的癌症以及癌症易感综合症中也发现了MDF。而且，最近的亮点来自在用抗生素处理后在真核细胞中对MDF的检测。在这篇综述中，我们集中于病理条件下MDF的最新研究，特别着重于各种抗生素对线粒体的影响。特别注意自噬/有丝分裂在中密度纤维板中的作用以及将抗生素重新用作抗癌药物。