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Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart
Theranostics ( IF 12.4 ) Pub Date : 2017-05-02 , DOI: 10.7150/thno.16866
Wenshuo Wang , Hongyue Tao , Yun Zhao , Xiaotian Sun , Jing Tang , Cordelia Selomulya , Jia Tang , Tianchan Chen , Yang Wang , Minglei Shu , Lei Wei , Guanyu Yi , Jixue Zhou , Lai Wei , Chunsheng Wang , Biao Kong

The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients. In addition, rat models with myocardial infraction showed sustained heart tissue regeneration over the infract region and significant improvement of cardiac functions following the surgical implantation of the framework. These results demonstrated that the current framework might hold great potential for cardiac repair in patients with myocardial infraction.

中文翻译:

植入式和可生物降解的大孔氧化铁骨架,可有效再生和修复心肌梗塞

这项研究报道了基于多层氧化铁的大孔复合框架的构造,表征和外科应用。该框架由高度多孔的氧化铁核,明胶基水凝胶中间层和基质胶外层组成,具有多种理想的性能,包括出色的生物相容性,改善的机械强度和可控制的生物降解性。框架的大孔径和高度的孔互连性刺激了稳健的新血管形成,并由于提高了对氧气和养分的转运效率而导致了更好的细胞活力和增殖。此外,患有心肌梗塞的大鼠模型显示,在该梗塞区域持续进行心脏组织再生,并在外科手术植入框架后显着改善了心脏功能。这些结果表明,当前的框架在心肌梗死患者中可能具有巨大的心脏修复潜力。
更新日期:2017-07-01
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