Tumour evolution, which results in the existence of multiple distinct populations of cancer cells within the same tumour and the same patient, is increasingly appreciated to have a key role in drug resistance. In this article, we discuss the implications for drug development, including approaches to reduce the likelihood of the emergence of drug resistance.

中文翻译：

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癌症演变对药物开发的影响

人们越来越认识到，导致同一肿瘤和同一患者内存在多个不同癌细胞群的肿瘤进化在耐药性中起着关键作用。在本文中，我们讨论了对药物开发的影响，包括减少药物耐药性出现的可能性的方法。