Overactivity of the transcription factor MYC plays a central part in the progression of multiple myeloma through upregulation of ribosome synthesis and translation activity. Using a high-throughput screening approach, Manier et al. have identified a series of synthetic analogues of the rocaglate natural product

中文翻译：

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癌症：针对MYC驱动的翻译

转录因子MYC的过度活性通过核糖体合成和翻译活性的上调在多发性骨髓瘤的进展中起着中心作用。使用高通量筛选方法，Manier等人。已经鉴定出草酸盐天然产物的一系列合成类似物