Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic.

中文翻译：

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自噬的药理学调节：治疗潜力和持续存在的障碍

自噬是在生理和病理情况下维持机体稳态的关键。因此，自噬的改变已与多种临床相关疾病相关，如癌症，神经退行性疾病和心脏疾病。在过去的十年中，自噬作为一种新型疗法的开发目标已引起了相当大的关注。但是，这种努力尚未产生临床上可行的干预措施。在这篇综述中，我们讨论了自噬调节剂的治疗潜力，分析了限制其发展的障碍，并提出了可能在临床中释放自噬调节剂全部治疗潜力的策略。