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Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Nature Genetics ( IF 30.8 ) Pub Date : 2017-05-22 00:00:00 , DOI: 10.1038/ng.3874 Joanna M M Howson , , Wei Zhao , Daniel R Barnes , Weang-Kee Ho , Robin Young , Dirk S Paul , Lindsay L Waite , Daniel F Freitag , Eric B Fauman , Elias L Salfati , Benjamin B Sun , John D Eicher , Andrew D Johnson , Wayne H H Sheu , Sune F Nielsen , Wei-Yu Lin , Praveen Surendran , Anders Malarstig , Jemma B Wilk , Anne Tybjærg-Hansen , Katrine L Rasmussen , Pia R Kamstrup , Panos Deloukas , Jeanette Erdmann , Sekar Kathiresan , Nilesh J Samani , Heribert Schunkert , Hugh Watkins , Ron Do , Daniel J Rader , Julie A Johnson , Stanley L Hazen , Arshed A Quyyumi , John A Spertus , Carl J Pepine , Nora Franceschini , Anne Justice , Alex P Reiner , Steven Buyske , Lucia A Hindorff , Cara L Carty , Kari E North , Charles Kooperberg , Eric Boerwinkle , Kristin Young , Mariaelisa Graff , Ulrike Peters , Devin Absher , Chao A Hsiung , Wen-Jane Lee , Kent D Taylor , Ying-Hsiang Chen , I-Te Lee , Xiuqing Guo , Ren-Hua Chung , Yi-Jen Hung , Jerome I Rotter , Jyh-Ming J Juang , Thomas Quertermous , Tzung-Dau Wang , Asif Rasheed , Philippe Frossard , Dewan S Alam , Abdulla al Shafi Majumder , Emanuele Di Angelantonio , Rajiv Chowdhury , Yii-Der Ida Chen , Børge G Nordestgaard , Themistocles L Assimes , John Danesh , Adam S Butterworth , Danish Saleheen ,
Nature Genetics ( IF 30.8 ) Pub Date : 2017-05-22 00:00:00 , DOI: 10.1038/ng.3874 Joanna M M Howson , , Wei Zhao , Daniel R Barnes , Weang-Kee Ho , Robin Young , Dirk S Paul , Lindsay L Waite , Daniel F Freitag , Eric B Fauman , Elias L Salfati , Benjamin B Sun , John D Eicher , Andrew D Johnson , Wayne H H Sheu , Sune F Nielsen , Wei-Yu Lin , Praveen Surendran , Anders Malarstig , Jemma B Wilk , Anne Tybjærg-Hansen , Katrine L Rasmussen , Pia R Kamstrup , Panos Deloukas , Jeanette Erdmann , Sekar Kathiresan , Nilesh J Samani , Heribert Schunkert , Hugh Watkins , Ron Do , Daniel J Rader , Julie A Johnson , Stanley L Hazen , Arshed A Quyyumi , John A Spertus , Carl J Pepine , Nora Franceschini , Anne Justice , Alex P Reiner , Steven Buyske , Lucia A Hindorff , Cara L Carty , Kari E North , Charles Kooperberg , Eric Boerwinkle , Kristin Young , Mariaelisa Graff , Ulrike Peters , Devin Absher , Chao A Hsiung , Wen-Jane Lee , Kent D Taylor , Ying-Hsiang Chen , I-Te Lee , Xiuqing Guo , Ren-Hua Chung , Yi-Jen Hung , Jerome I Rotter , Jyh-Ming J Juang , Thomas Quertermous , Tzung-Dau Wang , Asif Rasheed , Philippe Frossard , Dewan S Alam , Abdulla al Shafi Majumder , Emanuele Di Angelantonio , Rajiv Chowdhury , Yii-Der Ida Chen , Børge G Nordestgaard , Themistocles L Assimes , John Danesh , Adam S Butterworth , Danish Saleheen ,
Joanna Howson and colleagues perform a genome-wide association study and meta-analysis for coronary artery disease in large, trans-ancestry cohorts. They identify 15 new loci and correlate these regions with cell-type-specific gene expression and plasma protein levels to find novel pathways and potential mechanisms of disease.
中文翻译：
十五个新的冠状动脉疾病风险位点突显了动脉壁特异性机制
乔安娜·霍森（Joanna Howson）及其同事对大型跨祖先人群的冠状动脉疾病进行了全基因组关联研究和荟萃分析。他们确定了15个新基因座，并将这些区域与细胞类型特异性基因表达和血浆蛋白水平相关联，以找到新的途径和疾病的潜在机制。
更新日期：2017-06-29
中文翻译：
十五个新的冠状动脉疾病风险位点突显了动脉壁特异性机制
乔安娜·霍森（Joanna Howson）及其同事对大型跨祖先人群的冠状动脉疾病进行了全基因组关联研究和荟萃分析。他们确定了15个新基因座，并将这些区域与细胞类型特异性基因表达和血浆蛋白水平相关联，以找到新的途径和疾病的潜在机制。
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