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A Bright Future for Antibiotics?
Annual Review of Biochemistry ( IF 16.6 ) Pub Date : 2017-06-27 00:00:00 , DOI: 10.1146/annurev-biochem-061516-044617
Donna Matzov 1 , Anat Bashan 1 , Ada Yonath 1
Affiliation  

Multidrug resistance is a global threat as the clinically available potent antibiotic drugs are becoming exceedingly scarce. For example, increasing drug resistance among gram-positive bacteria is responsible for approximately one-third of nosocomial infections. As ribosomes are a major target for these drugs, they may serve as suitable objects for novel development of next-generation antibiotics. Three-dimensional structures of ribosomal particles from Staphylococcus aureus obtained by X-ray crystallography have shed light on fine details of drug binding sites and have revealed unique structural motifs specific for this pathogenic strain, which may be used for the design of novel degradable pathogen-specific, and hence, environmentally friendly drugs.

中文翻译:


抗生素的光明前景?

随着临床上有效的抗生素药物的日益匮乏,多药耐药性成为全球性威胁。例如,革兰氏阳性细菌中耐药性的增加约占医院感染的三分之一。由于核糖体是这些​​药物的主要靶标,因此它们可作为下一代抗生素新开发的合适对象。通过X射线晶体学获得的金黄色葡萄球菌核糖体颗粒的三维结构揭示了药物结合位点的精细细节,并揭示了该病原菌株特有的独特结构基序,可用于设计新型可降解病原体-特定的环保药品。

更新日期:2017-06-27
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