The review highlights the hydantoin syntheses presented from the point of view of the preparation methods. Novel synthetic routes to various hydantoin structures, the advances brought to the classical methods in the aim of producing more sustainable and environmentally friendly procedures for the preparation of these biomolecules, and a critical comparison of the different synthetic approaches developed in the last twelve years are also described. The review is composed of 95 schemes, 8 figures and 528 references for the last 12 years and includes the description of the hydantoin-based marketed drugs and clinical candidates.

中文翻译：

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乙内酰脲合成的最新进展：有价值的支架的艺术现状。

本文从制备方法的角度重点介绍了乙内酰脲合成方法。各种乙内酰脲结构的新颖合成途径，经典方法的进展，目的是产生制备这些生物分子的更具可持续性和环境友好性的方法，并对过去十二年来开发的不同合成方法进行了严格的比较。描述。该审查由过去12年的95个方案，8个数字和528份参考文献组成，并包括对基于乙内酰脲的市售药物和临床候选药物的描述。