With singlet oxygen (¹O₂) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H₂O₂ and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e.g. captivity and release), are described as a key point in the article. This review provide a general overview of designing novel PS or strategies for effective and controllable PDT.

中文翻译：

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通过调节单线态氧效率实现可控光动力治疗

以单线态氧（¹ O ₂）作为活性剂，光动力疗法（PDT）是治疗各种肿瘤和癌症的一种有前景的技术。但大多数传统光敏剂（PS）的选择性较差，阻碍了它的发展。在这篇综述中，我们总结了通过调节单线态氧效率实施的可控 PDT。本文总结并介绍了基于不同引发条件（如pH、光、H ₂ O ₂等）的各种可控PDT策略。更重要的是，可控PDT策略的作用机制，如光诱导电子转移（PET）、荧光共振能量转移（FRET）、分子内电荷转移（ICT）和一些物理/化学手段（例如俘获和释放）被描述为文章中的一个关键点。本综述对设计新颖的 PS 或有效且可控的 PDT 策略进行了总体概述。