Research and industrial interest in radical C–H activation/radical cross-coupling chemistry has continuously grown over the past few decades. These reactions offer fascinating and unconventional approaches toward connecting molecular fragments with high atom- and step-economy that are often complementary to traditional methods. Success in this area of research was made possible through the development of photocatalysis and first-row transition metal catalysis along with the use of peroxides as radical initiators. This Review provides a brief and concise overview of the current status and latest methodologies using radicals or radical cations as key intermediates produced via radical C–H activation. This Review includes radical addition, radical cascade cyclization, radical/radical cross-coupling, coupling of radicals with M–R groups, and coupling of radical cations with nucleophiles (Nu).

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自由基C–H活化/自由基交叉偶联的最新进展

在过去的几十年中，对自由基C–H活化/自由基交叉偶联化学的研究和工业兴趣不断增长。这些反应提供了引人入胜的非常规方法来连接具有高原子经济性和阶梯经济性的分子片段，这通常是对传统方法的补充。通过光催化和第一行过渡金属催化的发展以及使用过氧化物作为自由基引发剂，在该研究领域的成功成为可能。本综述简要概述了使用自由基或自由基阳离子作为通过CH-H活化产生的关键中间体的当前状态和最新方法。该评论包括自由基加成，自由基级联环化，自由基/自由基交叉偶联，自由基与M–R基团的偶联，