New, safe and effective drugs are urgently needed to treat and control malaria and tuberculosis, which affect millions of people annually. However, financial return on investment in the poor settings where these diseases are mostly prevalent is very minimal to support market-driven drug discovery and development. Moreover, the imminent loss of therapeutic lifespan of existing therapies due to evolution and spread of drug resistance further compounds the urgency to identify novel effective drugs. However, the advent of new public–private partnerships focused on tropical diseases and the recent release of large data sets by pharmaceutical companies on antimalarial and antituberculosis compounds derived from phenotypic whole cell high throughput screening have spurred renewed interest and opened new frontiers in malaria and tuberculosis drug discovery.

中文翻译：

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疟疾和结核病药物发现中潜在铅合成和目标识别的见解

迫切需要新的，安全和有效的药物来治疗和控制疟疾和结核病，这些疾病每年影响数百万人。但是，在这些疾病普遍流行的贫困地区，投资的财务回报很小，不足以支持市场驱动型药物的发现和开发。而且，由于耐药性的发展和扩散，现有疗法的治疗寿命即将丧失，这进一步加剧了鉴定新型有效药物的紧迫性。然而，