The selective oxidation of organic molecules is a fundamentally important component of modern synthetic chemistry. In the past decades, direct oxidative C–H and C–C bond functionalization has proved to be one of the most efficient and straightforward methods to synthesize complex products from simple and readily available starting materials. Among these oxidative processes, the use of molecular oxygen as a green and sustainable oxidant has attracted considerable attention because of its highly atom-economical, abundant, and environmentally friendly characteristics. The development of new protocols using molecular oxygen as an ideal oxidant is highly desirable in oxidation chemistry. More importantly, the oxygenation reaction of simple molecules using molecular oxygen as the oxygen source offers one of the most ideal processes for the construction of O-containing compounds. Aerobic oxidation and oxygenation by enzymes, such as monooxygenase, tyrosinase, and dopamine β-monooxygenase, have been observed in some biological C–H bond hydroxylation processes. Encouraged by these biological transformations, transition-metal- or organocatalyst-catalyzed oxygenation through dioxygen activation has attracted academic and industrial prospects.

中文翻译：

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通过分子氧通过C–H / C–C键活化进行氧合

有机分子的选择性氧化是现代合成化学的基本重要组成部分。在过去的几十年中，直接氧化C–H和C–C键功能化已被证明是从简单易得的起始原料合成复杂产物的最有效，最直接的方法之一。在这些氧化过程中，由于分子氧具有高度的原子经济性，丰富性和环境友好性，使用分子氧作为绿色和可持续的氧化剂已引起了广泛的关注。在氧化化学中非常需要开发使用分子氧作为理想氧化剂的新方案。更重要的是，使用分子氧作为氧源的简单分子的氧化反应为构建含O化合物提供了最理想的方法之一。在某些生物学的C–H键羟基化过程中，已经观察到有氧氧化和氧化作用，例如单加氧酶，酪氨酸酶和多巴胺β-单加氧酶。在这些生物转化的鼓舞下，通过双氧活化的过渡金属或有机催化剂催化的氧化已经吸引了学术和工业前景。