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Plasmonic Imaging of Electrochemical Impedance
Annual Review of Analytical Chemistry ( IF 8 ) Pub Date : 2017-06-12 00:00:00 , DOI: 10.1146/annurev-anchem-061516-045150
Liang Yuan 1 , Nongjian Tao 1, 2 , Wei Wang 1
Affiliation  

Electrochemical impedance spectroscopy (EIS) measures the frequency spectrum of an electrochemical interface to resist an alternating current. This method allows label-free and noninvasive studies on interfacial adsorption and molecular interactions and has applications in biosensing and drug screening. Although powerful, traditional EIS lacks spatial resolution or imaging capability, hindering the study of heterogeneous electrochemical processes on electrodes. We have recently developed a plasmonics-based electrochemical impedance technique to image local electrochemical impedance with a submicron spatial resolution and a submillisecond temporal resolution. In this review, we provide a systematic description of the theory, instrumentation, and data analysis of this technique. To illustrate its present and future applications, we further describe several selected samples analyzed with this method, including protein microarrays, two-dimensional materials, and single cells. We conclude by summarizing the technique's unique features and discussing the remaining challenges and new directions of its application.

中文翻译:


电化学阻抗的等离子成像

电化学阻抗谱(EIS)测量电化学界面的频谱以抵抗交流电。这种方法可以进行无标记的界面吸附和分子相互作用的无创研究,并已在生物传感和药物筛选中得到应用。传统的EIS尽管功能强大,但缺乏空间分辨率或成像功能,从而阻碍了电极上异质电化学过程的研究。我们最近开发了一种基于等离子体的电化学阻抗技术,以亚微米级的空间分辨率和亚毫秒级的时间分辨率对局部电化学阻抗进行成像。在这篇综述中,我们提供了对该技术的理论,仪器和数据分析的系统描述。为了说明其当前和将来的应用,我们进一步描述了用这种方法分析的几种选定样品,包括蛋白质微阵列,二维材料和单细胞。最后,我们总结了该技术的独特功能,并讨论了该技术尚存的挑战和新的发展方向。

更新日期:2017-06-12
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