This review examines the state of the art in synthesis as it relates to the building of complex architectures on scales sufficient to drive human drug trials. We focus on the relatively few instances in which a natural-product-based development candidate has been manufactured de novo, rather than semisynthetically. This summary provides a view of the strengths and weaknesses of current technologies, provides perspective on what one might consider a practical contribution, and hints at directions the field might take in the future.

中文翻译：

---

探索“实用”的边界：复杂的基于天然产物的候选药物的从头合成

这篇综述审查了合成的最新技术，因为它涉及到足以推动人类药物试验的规模的复杂体系结构的构建。我们关注的是从零开始而不是半合成地生产基于天然产物的开发候选产品的相对较少的情况。本摘要概述了当前技术的优势和劣势，提供了对人们可能会考虑的实际贡献的观点，并暗示了该领域未来的发展方向。