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From One to Many: Further Refinement of Medulloblastoma Subtypes Offers Promise for Personalized Therapy.
Cancer Cell ( IF 50.3 ) Pub Date : 2017-06-12 , DOI: 10.1016/j.ccell.2017.05.013
Abhishek Bavle , D. Williams Parsons

There is significant intertumoral heterogeneity within the four molecular subgroups of medulloblastoma. In this issue of Cancer Cell, Cavalli et al. apply similarity network fusion to gene expression and DNA methylation data to identify 12 medulloblastoma subtypes with distinct molecular and clinical profiles, making an important step toward molecularly tailored therapy.

中文翻译:

从一个到很多:进一步完善髓母细胞瘤亚型为个性化治疗提供了希望。

在髓母细胞瘤的四个分子亚组中存在明显的肿瘤间异质性。在本期《癌细胞》中,Cavalli等人。将相似性网络融合应用于基因表达和DNA甲基化数据,以鉴定具有不同分子和临床特征的12种髓母细胞瘤亚型,这是朝着分子定制疗法迈出的重要一步。
更新日期:2017-06-13
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