Annual Review of Biochemistry ( IF 16.6 ) Pub Date : 2016-06-13 00:00:00 , DOI: 10.1146/annurev-biochem-060815-014451 Celine E. Riera 1, 2, 3 , Carsten Merkwirth 1, 2, 3 , C. Daniel De Magalhaes Filho 2, 4 , Andrew Dillin 1, 2, 3
The health of an organism is orchestrated by a multitude of molecular and biochemical networks responsible for ensuring homeostasis within cells and tissues. However, upon aging, a progressive failure in the maintenance of this homeostatic balance occurs in response to a variety of endogenous and environmental stresses, allowing the accumulation of damage, the physiological decline of individual tissues, and susceptibility to diseases. What are the molecular and cellular signaling events that control the aging process and how can this knowledge help design therapeutic strategies to combat age-associated diseases? Here we provide a comprehensive overview of the evolutionarily conserved biological processes that alter the rate of aging and discuss their link to disease prevention and the extension of healthy life span.
中文翻译：
确定寿命的信令网络
生物的健康由负责确保细胞和组织内动态平衡的众多分子和生化网络来协调。然而，随着年龄的增长，响应于各种内源性和环境压力，维持这种稳态平衡的过程逐渐失败，从而导致损伤的积累，单个组织的生理衰退以及对疾病的易感性。控制衰老过程的分子和细胞信号传导事件是什么？这些知识如何帮助设计与年龄相关疾病的治疗策略？在这里，我们提供了进化保守的生物过程的全面概述，这些过程改变了衰老的速度，并讨论了它们与疾病预防和延长健康寿命的联系。
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