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The Coupled Chemical and Physical Dynamics Model of MALDI
Annual Review of Analytical Chemistry ( IF 8 ) Pub Date : 2016-06-15 00:00:00 , DOI: 10.1146/annurev-anchem-071015-041750
Richard Knochenmuss 1
Affiliation  

The coupled physical and chemical dynamics model of ultraviolet matrix-assisted laser desorption/ionization (MALDI) has reproduced and explained a wide variety of MALDI phenomena. The rationale behind and elements of the model are reviewed, including the photophysics, kinetics, and thermodynamics of primary and secondary reaction steps. Experimental results are compared with model predictions to illustrate the foundations of the model, coupling of ablation and ionization, differences between and commonalities of matrices, secondary charge transfer reactions, ionization in both polarities, fluence and concentration dependencies, and suppression and enhancement effects.

中文翻译:


MALDI的化学和物理动力学耦合模型

紫外线基质辅助激光解吸/电离(MALDI)的耦合物理和化学动力学模型已经再现并解释了多种MALDI现象。审查了模型的基本原理和元素,包括一级和二级反应步骤的光物理,动力学和热力学。将实验结果与模型预测结果进行比较,以说明模型的基础,烧蚀和电离的耦合,基质之间的共性和差异,二次电荷转移反应,极性的电离,能量密度和浓度依赖性以及抑制和增强效果。

更新日期:2016-06-15
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