Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding parts act as antisense RNAs to regulate the translation and/or the stability of mRNAs encoding transcriptional regulators, major virulence factors, and cell wall metabolism enzymes. In this review, we explain how regulatory proteins and RNAIII are embedded in complex regulatory circuits to express virulence factors in a dynamic and timely manner in response to stress and environmental and metabolic changes.

中文翻译：

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金黄色葡萄球菌RNAIII及其调节子调控群感应，应激反应，代谢适应和毒力基因表达的调节。

金黄色葡萄球菌RNAIII是群体感应系统的主要细胞内效应子之一。它是编码小肽的多功能RNA，其非编码部分充当反义RNA，以调节编码转录调节因子，主要毒力因子和细胞壁代谢酶的mRNA的翻译和/或稳定性。在这篇综述中，我们解释了调节蛋白和RNAIII如何嵌入复杂的调节回路中，以动态，及时地响应压力以及环境和代谢变化来表达毒力因子。