Protein–protein interactions (PPIs) are ubiquitous in biological systems and often misregulated in disease. As such, specific PPI modulators are desirable to unravel complex PPI pathways and expand the number of druggable targets available for therapeutic intervention. However, the large size and relative flatness of PPI interfaces make them challenging molecular targets. This Account describes our systematic approach using secondary and tertiary protein domain mimics (PDMs) to specifically modulate PPIs.

中文翻译：

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蛋白质结构域模拟物作为蛋白质-蛋白质相互作用的调节剂。

蛋白质之间的相互作用（PPI）在生物系统中无处不在，并且在疾病中常常被错误地调节。因此，需要特定的PPI调节剂来揭示复杂的PPI途径并扩大可用于治疗干预的可药物靶向的数量。但是，PPI界面的大尺寸和相对平坦性使其成为挑战性的分子靶标。该帐户描述了我们使用二级和三级蛋白质域模拟物（PDM）专门调节PPI的系统方法。