Peroxisome proliferator-activated receptor-γ co-activator 1α (PGC1α) plays a pivotal part in energy homeostasis and is involved in the regulation of gluconeogenesis. Using a cell-based high-throughput chemical screen, Sharabi et al. have identified a small molecule, SR-18292, that increases acetylation of PGC1α, which results in

中文翻译：

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代谢性疾病：抑制PGC1α可改善糖尿病

过氧化物酶体增殖物激活受体-γ共激活物1α（PGC1α）在能量稳态中起关键作用，并参与糖异生的调节。Sharabi等人使用基于细胞的高通量化学筛选。已经鉴定出一个小分子SR-18292，它可以增加PGC1α的乙酰化程度，从而导致