A novel class of bioorthogonal release reactions based on benzonorbornadiene derivatives was developed. These carrier molecules are highly stable at physiological conditions, but react rapidly with 1,2,4,5-tetrazines, and near-quantitatively release cargo molecules such as drugs and optical reporters.

中文翻译：

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快速和有效的四嗪诱导的药物从高度稳定的苯并降冰片二烯衍生物中释放

开发了基于苯并降冰片二烯衍生物的一类新型的生物正交释放反应。这些载体分子在生理条件下高度稳定，但可与1,2,4,5-四嗪快速反应，并以接近定量的方式释放货物分子，例如药物和光学报告分子。