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The Structure of the Elusive Simplest Dipeptide Gly-Gly
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2017-04-28 04:45:33 , DOI: 10.1002/anie.201702425
Carlos Cabezas 1 , Marcelino Varela 1 , José L. Alonso 1
Affiliation  

Among the hundreds of peptide compounds for which conformations have been determined by using different spectroscopic techniques, the structure of the simplest dipeptide glycylglycine (Gly-Gly) is conspicuously absent. Herein, for the first time, solid samples of Gly-Gly have been vaporized by laser ablation and three different structures have been revealed in a supersonic expansion by Fourier transform microwave spectroscopy. The intramolecular hydrogen bonding interactions that stabilize the observed forms have been established based on the 14N nuclear quadrupole hyperfine structure. We have illustrated how conformer interconversion distorts the equilibrium conformational distribution, giving rise to missing conformers in the conformational landscape.

中文翻译:

最难以捉摸的二肽Gly-Gly的结构

在通过使用不同的光谱技术确定构象的数百种肽化合物中,最简单的二肽甘氨酰甘氨酸(Gly-Gly)的结构明显缺乏。在此,Gly-Gly的固体样品首次通过激光烧蚀而蒸发,并且通过傅立叶变换微波光谱在超音速膨胀中揭示了三种不同的结构。基于14 N核四极超精细结构,已建立了稳定观察形式的分子内氢键相互作用。我们已经说明了构象异构体互变如何扭曲平衡构象分布,从而导致构象景观中缺少构象异构体。
更新日期:2017-05-24
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