The potential commercial applications for metal organic frameworks (MOFs) are tantalizing. To address the opportunity, many novel approaches for their synthesis have been developed recently. These strategies present a critical step towards harnessing the myriad of potential applications of MOFs by enabling larger scale production and hence real-world applications. This review provides an up-to-date survey ( references) of the most promising novel synthetic routes, i.e., electrochemical, microwave, mechanochemical, spray drying and flow chemistry synthesis. Additionally, the essential topic of downstream processes, especially for large scale synthesis, is critically reviewed. Lastly we present the current state of MOF commercialization with direct feedback from commercial players.

中文翻译：

---

大规模生产MOF的新合成路线

金属有机骨架（MOF）的潜在商业应用正在诱人。为了解决这个机会，最近已经开发了许多新颖的合成方法。这些策略通过实现大规模生产以及实际应用，为利用MOF的众多潜在应用提供了关键的一步。这篇综述提供了最有前途的新颖合成途径的最新调查（参考），即电化学，微波，机械化学，喷雾干燥和流化学合成。另外，严格审查了下游过程的基本主题，尤其是大规模合成的下游过程。最后，我们从商业参与者的直接反馈中介绍了MOF商业化的现状。