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Methods Utilizing First-Row Transition Metals in Natural Product Total Synthesis
Chemical Reviews ( IF 62.1 ) Pub Date : 2017-05-19 00:00:00 , DOI: 10.1021/acs.chemrev.6b00833
Joshua E. Zweig 1 , Daria E. Kim 1 , Timothy R. Newhouse 1
Affiliation  

First-row transition-metal-mediated reactions constitute an important and growing area of research due to the low cost, low toxicity, and exceptional synthetic versatility of these metals. Currently, there is considerable effort to replace existing precious-metal-catalyzed reactions with first-row analogs. More importantly, there are a plethora of unique transformations mediated by first-row metals, which have no classical second- or third-row counterpart. Herein, the application of first-row metal-mediated methods to the total synthesis of natural products is discussed. This Review is intended to highlight strategic uses of these metals to realize efficient syntheses and highlight the future potential of these reagents and catalysts in organic synthesis.

中文翻译:

在天然产物全合成中使用第一行过渡金属的方法

由于这些金属的低成本,低毒性和出色的合成多功能性,第一行过渡金属介导的反应构成了一个重要且不断发展的研究领域。当前,有相当大的努力用第一行类似物代替现有的贵金属催化的反应。更重要的是,第一行金属介导了许多独特的转变,而没有经典的第二行或第三行金属。在此,讨论了第一行金属介导的方法在天然产物的全合成中的应用。这篇综述旨在突出这些金属的战略用途,以实现有效的合成,并突出这些试剂和催化剂在有机合成中的未来潜力。
更新日期:2017-05-19
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