Ammonia-lyases and aminomutases are mechanistically and structurally diverse enzymes which catalyze the deamination and/or isomerization of amino acids in nature by cleaving or shifting a C-N bond. Of the many protein families in which these enzyme activities are found, only a subset have been employed in the synthesis of optically pure fine chemicals or in medical applications. This review covers the natural diversity of these enzymes, highlighting particular enzyme classes that are used within industrial and medical biotechnology. These highlights detail the discovery and mechanistic investigations of these commercially relevant enzymes, along with comparisons of their various applications as stand-alone catalysts, components of artificial biosynthetic pathways and biocatalytic or chemoenzymatic cascades, and therapeutic tools for the potential treatment of various pathologies.

中文翻译：

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氨裂解酶和氨基酸突变酶的合成和治疗应用。

氨裂合酶和氨基变位酶是机械上和结构上不同的酶，其通过切割或移位CN键催化自然界中氨基酸的脱氨和/或异构化。在发现这些酶活性的许多蛋白质家族中，只有一部分用于光学纯精细化学品的合成或医学应用。这篇综述涵盖了这些酶的自然多样性，重点介绍了在工业和医学生物技术中使用的特定酶类别。这些亮点详细介绍了这些与商业相关的酶的发现和机理研究，以及它们作为独立催化剂，人工生物合成途径的组分以及生物催化或化学酶联反应的各种应用的比较，