Sulfur plays a critical role for the development and maintenance of life on earth, which is reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this element. Whereas a large body of knowledge has existed for sulfur trafficking in primary metabolism, the secondary metabolism involving sulfur has long been neglected. Yet, diverse sulfur functionalities have a major impact on the biological activities of natural products. Recent research at the genetic, biochemical, and chemical levels has unearthed a broad range of enzymes, sulfur shuttles, and chemical mechanisms for generating carbon–sulfur bonds. This Review will give the first systematic overview on enzymes catalyzing the formation of organosulfur natural products.

中文翻译：

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天然产物生物合成中的酶促碳硫键形成

硫对于地球生命的发展和维持起着至关重要的作用，这可以通过大量的主要代谢产物，大分子和带有这种元素的辅因子来体现。尽管已经存在大量有关初级代谢中硫运输的知识，但长期以来一直忽略了涉及硫的次级代谢。然而，多种硫官能度对天然产物的生物活性具有重大影响。最近在遗传，生化和化学方面的研究发现了范围广泛的酶，硫穿梭和产生碳硫键的化学机理。这篇综述将对催化有机硫天然产物形成的酶进行系统的首次综述。