Development Lung morphogenesis is a complex process involving rearrangements of various cell types to achieve the branched patterning necessary to maximize gaseous exchange. Lin et al. found that YAP, a component of the Hippo pathway known to be important for organ size regulation, is required for branching. YAP is expressed throughout the murine lung epithelium. Local inhibition of YAP decreases local cell proliferation, which means inadequate force is produced to move cells and form airway branches. Genomic analysis showed that YAP regulates levels of pMLC (phosphorylated myosin light chain), which is required for cells to produce mechanical force. The YAP mechanism may also be involved in branching in other tissues. eLife 10.7554/eLife.21130 (2017). ![Figure][1] Regulation of motor proteins forces developing tissues to branch. PHOTO: BIOPHOTO ASSOCIATES/SCIENCE SOURCE [1]: pending:yes

中文翻译：

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YAP 对肺分支形态发生至关重要

发育 肺形态发生是一个复杂的过程，涉及各种细胞类型的重排，以实现最大化气体交换所需的分支模式。林等人。发现 YAP 是 Hippo 通路的一个组成部分，已知对器官大小调节很重要，是分支所必需的。YAP 在整个鼠肺上皮细胞中表达。YAP 的局部抑制会减少局部细胞增殖，这意味着产生的力不足以移动细胞并形成气道分支。基因组分析表明，YAP 调节 pMLC（磷酸化肌球蛋白轻链）的水平，这是细胞产生机械力所必需的。YAP 机制也可能与其他组织的分支有关。eLife 10.7554/eLife.21130 (2017)。![图][1] 运动蛋白的调节迫使发育中的组织分支。照片：