Immune Regulation Although expression of FoxP3 is largely synonymous with T regulatory (Treg) cell identity in mice, type 1 regulatory T cells (TR1) are an exception. TR1 cells produce interleukin-10 but are FoxP3-negative. In comparison with FoxP3-positive Treg cells, the development and functions of TR1 cells are poorly understood. Zhang et al. report that TR1 cells play a critical regulatory role after allogeneic bone marrow transplantation (BMT) in mice and use this model to delineate the molecular circuits driving commitment to the TR1 lineage. By documenting the presence of TR1 cells after BMT in humans, they propose that modulation of TR1 cells could be a therapeutic approach for increasing BMT success rates in the clinic. Sci. Immunol. 2 , eaah7152 (2017).

中文翻译：

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没有 FoxP3 的调节性 T 细胞

免疫调节 尽管 FoxP3 的表达在很大程度上与小鼠中的 T 调节 (Treg) 细胞特性同义，但 1 型调节 T 细胞 (TR1) 是一个例外。TR1 细胞产生白细胞介素 10，但 FoxP3 阴性。与 FoxP3 阳性 Treg 细胞相比，TR1 细胞的发育和功能知之甚少。张等人。报告称，TR1 细胞在小鼠同种异体骨髓移植 (BMT) 后发挥关键调节作用，并使用该模型描绘驱动对 TR1 谱系的承诺的分子回路。通过记录人体 BMT 后 TR1 细胞的存在，他们提出调节 TR1 细胞可能是提高临床 BMT 成功率的一种治疗方法。科学。免疫学。2、eaah7152（2017）。