Drug toxicity: Cardiac safety index for TKIs,Nature Reviews Drug Discovery

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Drug toxicity: Cardiac safety index for TKIs
Nature Reviews Drug Discovery ( IF 120.1 ) Pub Date : 2017-03-30 , DOI: 10.1038/nrd.2017.52
Sarah Crunkhorn

Tyrosine kinase inhibitors (TKIs) represent efficacious anticancer agents, but their use has been linked with severe cardiotoxicity. Here, Sharma et al. generated human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, hiPSC-derived endothelial cells and hiPSC-derived cardiac fibroblasts to evaluate the cardiotoxicities of 21 US FDA-approved

中文翻译：

药物毒性：TKI的心脏安全性指数

酪氨酸激酶抑制剂（TKIs）代表有效的抗癌药，但其使用已与严重的心脏毒性联系在一起。在这里，Sharma等人。产生人类诱导的多能干细胞（hiPSC）来源的心肌细胞，hiPSC来源的内皮细胞和hiPSC来源的心脏成纤维细胞来评估21种美国FDA批准的心脏毒性

更新日期：2017-04-11

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