Physiology Starvation stresses an animal and can cause tissue loss. Regeneration after refeeding seems to mimic developmental activation of cells and replenishes depleted tissues. Cheng et al. tested the effects on mice of a low-calorie (low in carbohydrates and protein) but high-fat diet that resembles the metabolic effects of fasting but is easier for humans to tolerate. In models of type 1 and type 2 diabetes, mice on this diet showed improved insulin secretion and glucose homeostasis. The diet promoted signaling and transcriptional changes reminiscent of those that occur during the development of pancreatic endocrine cells. The findings raise the possibility of reprogramming endogenous cells in the pancreas to restore function lost in diabetes. Cell 10.1016/j.cell.2017.01.040 (2017).

中文翻译：

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通过饥饿增强胰腺

生理学 饥饿会给动物带来压力，并可能导致组织损失。重新喂养后的再生似乎模拟细胞的发育激活并补充耗尽的组织。程等人。测试了低热量（低碳水化合物和蛋白质）但高脂肪饮食对小鼠的影响，这种饮食类似于禁食的代谢作用，但更易于人类耐受。在 1 型和 2 型糖尿病模型中，这种饮食的小鼠显示出胰岛素分泌和葡萄糖稳态的改善。饮食促进了信号和转录变化，让人想起胰腺内分泌细胞发育过程中发生的变化。这些发现提出了重新编程胰腺中的内源性细胞以恢复糖尿病失去的功能的可能性。单元格 10.1016/j.cell.2017.01.040 (2017)。