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Editorial note: Low temperature synthesis of carbon dots in microfluidic chip and their application for sensing cefquinome residues in milk [Biosens. Bioelectron. 228 (2023) 115187] Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-18 Guangming Li, Chen Liu, Xingcai Zhang, Peng Zhai, Xinyi Lai, Wenxiao Jiang
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Adaptively resettable microfluidic patch for sweat rate and electrolytes detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Mengyuan Liu, Siyuan Liu, Tong Zhang, Dengfeng Zhou, Lianhui Li, Qiang Gao, Yujie Liu, Changlei Ge, Yongfeng Wang, Mingxu Wang, Feng Wen, Zuoping Xiong, Zhen Zhou, Shuqi Wang, Ting Zhang
Skin-interfaced microfluidic patch has become a reliable device for sweat collection and analysis. However, the intractable problems of emptying the microchannel for reuse, and the channel's volumetric capacity limited by the size of the patch, directly hinder the practical application of sweat sensors. Herein, we report an adaptively resettable microfluidic sweat patch (Art-Sweat patch) capable of
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A rapid and sensitive one-pot platform integrating fluorogenic RNA aptamers and CRISPR-Cas13a for visual detection of monkeypox virus Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Xiao Wang, Xiaobao Deng, Yidun Zhang, Weiyi Dong, Qiao Rao, Qingmei Huang, Fei Tang, Rong Shen, Hongzhi Xu, Zhen Jin, Youzhi Tang, Dan Du
The recent global upsurge in Monkeypox virus (MPXV) outbreaks underscores the critical need for rapid and precise diagnostic solutions, particularly in resource-constrained settings. The gold standard diagnostic method, qRT-PCR, is hindered by its time-consuming nature, requirement for nucleic acid purification, expensive equipment, and the need for highly trained personnel. Traditional CRISPR/Cas
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Target proteins-regulated DNA nanomachine-electroactive substance complexes enable separation-free electrochemical detection of clinical exosome Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-14 Xianghu Zeng, Chengyong Wu, Ying Xiong, Zixuan Zhan, Congcong Shen, Feng Lin, Junlong Zhang, Piaopiao Chen
Simple and reliable profiling of tumor-derived exosomes (TDEs) holds significant promise for the early detection of cancer. Nonetheless, this remains challenging owing to the substantial heterogeneity and low concentration of TDEs. Herein, we devised an accurate and highly sensitive electrochemical sensing strategy for TDEs simultaneously targeting exosomal mucin 1 (MUC1) and programmed cell death
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Rapid and multi-target genotyping of Helicobacter pylori with digital microfluidics Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-11 Jinsong Liu, Rongxin Fu, Shuailong Zhang, Jialu Hou, Hanbin Ma, Siyi Hu, Hang Li, Yanli Zhang, Weian Wang, Bokang Qiao, Baisheng Zang, Xun Min, Feng Zhang, Jie Du, Shengkai Yan
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Controllable detection threshold achieved through the toehold switch system in a mercury ion whole-cell biosensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-09 Qinglong Zhang, Zixiang Wei, Xiaoqiang Jia
Due to the toxicity of mercury and its harmful effects on human health, it is essential to establish a low-cost, highly sensitive and highly specific monitoring method with a wide detection range, ideally with a simple visual readout. In this study, a whole-cell biosensor with adjustable detection limits was developed for the detection of mercury ions in water samples, allowing controllable threshold
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An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-09 Yong Yang, Can Sheng, Fang Dong, Sheng Liu
Monitoring biomarkers in human interstitial fluids (ISF) using microneedle sensors has been extensively studied. However, most of the previous studies were limited to simple in vitro demonstrations and lacked system integration and analytical performance. Here we report a miniaturized, high-precision, fully integrated wearable electrochemical microneedle sensing device that works with a customized
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An enzyme-free sensing platform for miRNA detection and in situ imaging in clinical samples based on DNAzyme cleavage-triggered catalytic hairpin assembly Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-09 Hechen Wang, Minzhe Shen, Xudan Shen, Jiatong Liu, Wenwen Huang, Xianfeng Jiang, Hui Liu, Su Zeng, Kewang Nan, Sheng Cai
MicroRNA (miRNA) is demonstrated to be associated with the occurrence and development of various diseases including cancer. Currently, most miRNA detection methods are confined to detection and cannot obtain information on the temporal and spatial expression of miRNA in relevant tissues and cells. In this work, we established a novel enzyme-free method that can be applied to both detection and imaging
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Graphene derivative-based ink advances inkjet printing technology for fabrication of electrochemical sensors and biosensors Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Martin-Alex Nalepa, David Panáček, Ivan Dědek, Petr Jakubec, Vojtěch Kupka, Vítězslav Hrubý, Martin Petr, Michal Otyepka
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An enzymatically activated AND-gate DNA logic circuit for tumor cells recognition via multi-microRNAs detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Hanrong Yan, Guojun Cao, Jin Wang, Xu Zhu, Shuqing Dong, Yuqi Huang, Minghao Chao, Yuting Li, Fenglei Gao, Lei Hua
The DNA-based logic circuit, constructed to mimic biochemical reaction networks, is highly significant in detecting biomarkers at the molecular level. The differences in the expression levels of microRNAs (miRNAs) within different types of cells provide hope for distinguishing cell subtypes. However, reliance on a single miRNA often leads to unreliable results. Herein, we constructed an enzyme-triggered
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Perovskite hydroxide-based laccase mimics with controllable activity for environmental remediation and biosensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Yufeng Liu, Jing Zhang, Shuai Cui, Hui Wei, Dongzhi Yang
Constructing relatively inexpensive nanomaterials to simulate the catalytic performance of laccase is of great significance in recent years. Although research on improving laccase-like activity by regulating ligands of copper (amino acids or small organic molecules, etc.) have achieved remarkable success. There are few reports on improving laccase-like activity by adjusting the composition of metal
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A photoelectrochemical biosensor based on self-calibration platform of carbon-rich plasmonic probe with near-infrared driving signal amplification Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Yanjie Chen, Yitian Huang, Shupei Zhang, Lihong Gao, Hong Dai
Exploring the photochemical (PEC) method induced by low-energy light source makes great significance to achieve high stability and accurate analysis. A sensing platform driven by near-infrared (NIR) light was designed by making the biochemically encoded carbon rich plasmonic hybrid (CPH) probe, the peptide@C–MoC. The inherent plasmonic effect of C–MoC CPH can directly absorb NIR light, thus starting
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Highly sensitive and selective demethylase FTO detection using a DNAzyme-mediated CRISPR/Cas12a signal cascade amplification electrochemiluminescence biosensor with C–CN/PCNV heterojunction as emitter Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-06 Hong Li, Shuai Qiao, Heng Zhang, Yanxia Qiao, Jin Liu, Yan Li
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Metabolism-triggered sensor array aided by machine learning for rapid identification of pathogens Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-06 Xin Wang, Huida Li, Chengxin Wu, Jianyu Yang, Jianhua Wang, Ting Yang
Chemical-nose strategy has achieved certain success in the discrimination and identification of pathogens. However, this strategy usually relies on non-specific interactions, which are prone to be significantly disturbed by the change of environment thus limiting its practical usefulness. Herein, we present a novel chemical-nose sensing approach leveraging the difference in the dynamic metabolic variation
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MXene/Hydrogel-based bioelectronic nose for the direct evaluation of food spoilage in both liquid and gas-phase environments Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Jing Liu, Youngju Nam, Danmin Choi, Yoonji Choi, Sang-Eun Lee, Honggyu Oh, Guangxian Wang, Seung Hwan Lee, Yuan Liu, Seunghun Hong
Various bioelectronic noses have been recently developed for mimicking human olfactory systems. However, achieving direct monitoring of gas-phase molecules remains a challenge for the development of bioelectronic noses due to the instability of receptor and the limitations of its surrounding microenvironment. Here, we report a MXene/hydrogel-based bioelectronic nose for the sensitive detection of liquid
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Detection of SARS-CoV-2 using machine learning-enabled paper-assisted ratiometric fluorescent sensors based on target-induced magnetic DNAzyme Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Wenhai Wang, Lun Luo, Yanmei Li, Bin Hong, Yi Ma, Keren Kang, Jufang Wang
The development of an advanced analytical platform with regard to SARS-CoV-2 is crucial for public health. Herein, we present a machine learning platform based on paper-assisted ratiometric fluorescent sensors for highly sensitive detection of the SARS-CoV-2 RdRp gene. The assay involves target-induced rolling circle amplification to generate magnetic DNAzyme, which is then detectable using the paper-assisted
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Hepatocellular carcinoma biomarkers screening based on hydrogel photonic barcodes with tyramine deposition amplified ELISA Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Wenjing Xue, Li Wang, Kexin Yi, Lingyu Sun, Haozhen Ren, Feika Bian
Hepatocellular carcinoma (HCC), as one of the most lethal cancers, significantly impacts human health. Attempts in this area tends to develop novel technologies with sensitive and multiplexed detection properties for early diagnosis. Here, we present novel hydrogel photonic crystal (PhC) barcodes with tyramine deposition amplified enzyme-linked immunosorbent assay (ELISA) for highly sensitive and multiplexed
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Coreactant-free aggregation-induced electrochemiluminescence system based on the novel zinc-luminol metal-organic gel for ultrasensitive detection of PiRNA-823 Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Congyi Hu, Liping Cao, Xinjie Wu, Gaoxu Chen, Yuanfang Li, Jian Wang, Chengzhi Huang, Lei Zhan
Aggregation-induced electrochemiluminescence (AIECL) technology has aroused widespread interest due to the significant improve in ECL response by solving the problems of aggregation-caused quenching and poor water solubility of the luminophore. However, the existing AIECL emitters still suffer from low ECL efficiency, additional coreactants and complex synthesis steps, which greatly limit their applications
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Construction of self-enhanced luminescence probes based on Ti3C2 reducibility for ultrasensitive PNK analysis Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-03 Zhihao Wei, Huixin Zhang, Feifei Zhang, Jianfei Xia, Qingyang Meng, Hongjie Huang, Zonghua Wang
Au nano-clusters (Au NCs) were promising electrochemiluminescence (ECL) nano-materials. However, the small size of Au NCs presented a challenge in terms of their immobilization during the construction of an ECL biosensing platform. This limitation significantly hindered the wider application of Au NCs in the ECL field. In this work, we successfully used the reducibility of TiC to fabricate a self-enhanced
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Two-dimensional metal-organic framework nanozyme-mediated portable paper-based analytical device for dichlorophen assay Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-03 Jiafu Chang, Ruixian Hu, Jinyan Zhang, Ting Hou, Feng Li
The metal-organic frameworks (MOFs) nanozyme-mediated paper-based analytical devices (PADs) have shown great potential in portable visual determination of phenolic compounds in the environment. However, most MOF nanozymes suffer from poor dispersibility and block-like structure, which often prompts deposition and results in diminished enzymatic activity, severely hindering their environmental applications
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High-throughput visualization mutation screening technology to enhance the specificity of CadR based whole-cell cadmium biosensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-02 Mingzhang Guo, Shijing Chen, Hongfei Su, Xiaolin Chen, Huilin Liu, Baoguo Sun
As a heavy metal pollutant, Cd often enters the human body through the food chain causing great harm to human health. Whole-cell biosensor is an emerging technology for rapid on-site detection of heavy metals with the advantages of inexpensive, fast to mass-produce, and strong in anti-interference resistance, but suffering from insatisfactory specificity. In this study, a strategy of Adjacent Site
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Flexible low-profile external ventricular drain catheter for real-time brain monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-02 Hoon Yi, Hodam Kim, Ka Ram Kim, Ju Hyeon Kim, Juhee Kim, Hyunjae Lee, Sanjeet S. Grewal, William D. Freeman, Woon-Hong Yeo
External ventricular drainage is one of the most common neurosurgical procedures in the world for acute hydrocephalus, which must be performed carefully by a neurosurgeon. Although various neuromonitoring external ventricular drain (EVD) catheters have been utilized, they still suffer from rigidity and bulkiness to mitigate post-EVD placement trauma. Here, we introduce a flexible and low-profile smart
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Nanozyme-assisted molecularly imprinted polymer-based indirect competitive ELISA for the detection of marine biotoxin Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-02 Chae Hwan Cho, Ji Hong Kim, Navnath S. Padalkar, Y. Veera Manohara Reddy, Tae Jung Park, Jinyoung Park, Jong Pil Park
Saxitoxin (STX), which is produced by certain dinoflagellate species, is a type of paralytic shellfish poisoning toxin that poses a serious threat to human health and the environment. Therefore, developing a technology for the convenient and cost-effective detection of STX is imperative. In this study, we developed an affinity peptide-imprinted polymer-based indirect competitive ELISA (ic-ELISA) without
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Fiber-optic immunosensor based on a Fabry–Perot interferometer for single-molecule detection of biomarkers Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-01 Haiming Qiu, Yong Yao, Yongkang Dong, Jiajun Tian
Immunosensors capable of ultralow-concentration and single-molecule detection of biomarkers are garnering attention for the early diagnosis of cancer. Herein, a fiber-optic Fabry–Perot interferometer (FPI)–based immunosensor was used for the first time for single-molecule detection of progastrin-releasing peptide (ProGRP). The cascaded FPI structure of the immunosensor introduces a high-order harmonic
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Advancing abiotic stress monitoring in plants with a wearable non-destructive real-time salicylic acid laser-induced-graphene sensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-31 Sammy A. Perdomo, Drochss Pettry Valencia, Gabriel Esteban Velez, Andres Jaramillo-Botero
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Ultrahigh peroxidase-like catalytic performance of Cu–N4 and Cu–N4S active sites-containing reduced graphene oxide for sensitive electrochemical biosensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-31 Phan Gia Le, Xuan Ai Le, Hai Sang Duong, Sung Hoon Jung, TaeYoung Kim, Moon Il Kim
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Automatic ultrasensitive lateral flow immunoassay based on a color-enhanced signal amplification strategy Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-30 Huiyang Jie, Yu Wang, Meng Zhao, Xiuzhen Wang, Zhong Wang, Lingliao Zeng, Xiaobao Cao, Tao Xu, Fan Xia, Qian Liu
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Modulus-tunable multifunctional hydrogel ink with nanofillers for 3D-Printed soft electronics Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-30 Minkyong Kang, Jae Park, Soo A Kim, Tae Young Kim, Ju Yeon Kim, Dae Woo Kim, Kijun Park, Jungmok Seo
Seamless integration and conformal contact of soft electronics with tissue surfaces have emerged as major challenges in realizing accurate monitoring of biological signals. However, the mechanical mismatch between the electronics and biological tissues impedes the conformal interfacing between them. Attempts have been made to utilize soft hydrogels as the bioelectronic materials to realize tissue-comfortable
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Biosensors for psychiatric biomarkers in mental health monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-29 Lin Wang, Yubing Hu, Nan Jiang, Ali K. Yetisen
Psychiatric disorders are associated with serve disturbances in cognition, emotional control, and/or behavior regulation, yet few routine clinical tools are available for the real-time evaluation and early-stage diagnosis of mental health. Abnormal levels of relevant biomarkers may imply biological, neurological, and developmental dysfunctions of psychiatric patients. Exploring biosensors that can
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A spatial-potential resolved bipolar electrode electrochemiluminescence biosensor based on polarity conversion for dual-mode detection of miRNA-122 and CEA Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Hongkun Li, Qianqian Cai, Zhikang Li, Guifen Jie, Hong Zhou
In this work, a spatial-potential resolved bipolar electrode electrochemiluminescence (BPE-ECL) biosensor based on polarity conversion strategy and CuHCF electrocatalyst was constructed for dual-mode detection of miRNA-122 and carcinoembryonic antigen (CEA). ECL technology was firstly used to systematically study the polarity conversion of BPE. It was found that changing the polarity of the driving
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Layer-by-layer growth of Cu3(HHTP)2 films on Cu(OH)2 nanowire arrays for high performance ascorbic acid sensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Chenhuinan Wei, Zhuo Wang, Yurun Hu, Jingqi Huang, Yang Zhang, Huihu Wang, Qiming Liu, Ziyang Yu
Growing three-dimensional (3D) metal organic frameworks (MOFs) via heterogeneous epitaxial growth on metal hydroxide arrays are effective for constructing electrochemical sensor. However, the growth of MOFs is difficult to control, resulting in thick and irregular morphologies and even damage the metal hydroxide template. In this work, Cu(HHTP) (HHTP = 2, 3, 6, 7, 10, 11-hexahydroxytriphenylene) films
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Dual toeholds regulated CRISPR-Cas12a sensing platform for ApoE single nucleotide polymorphisms genotyping Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Yuedong Zhu, Yanan Lin, Bin Gong, Yan Zhang, Gaoxing Su, Yanyan Yu
Single nucleotide polymorphisms (SNPs) are closely associated with many biological processes, including genetic disease, tumorigenesis, and drug metabolism. Accurate and efficient SNP determination has been proved pivotal in pharmacogenomics and diagnostics. Herein, a universal and high-fidelity genotyping platform is established based on the dual toeholds regulated Cas12a sensing methodology. Different
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Proximity labeling-assisted click conjugation for electrochemical analysis of specific subpopulations in circulating extracellular vesicles Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Yue Cao, Liang Zhou, Guozhang Zhou, Wensheng Liu, Haiyan Cui, Ya Cao, Xiaolei Zuo, Jing Zhao
Sensitive and accurate analysis of specific subpopulations in circulating extracellular vesicles (EVs) can provide a wealth of information for cancer diagnosis and management. Thus, we propose herein a new electrochemical biosensing method based on a proximity labeling-assisted click conjugation strategy. The method's core design is use of antibody-guided proximity labeling to equip target EVs with
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Fully integrated and automated centrifugal microfluidic chip for point-of-care multiplexed molecular diagnostics Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Yujin Xiao, Mengfan Zhou, Changgen Liu, Siyu Gao, Chao Wan, Shunji Li, Chenxi Dai, Wei Du, Xiaojun Feng, Yiwei Li, Peng Chen, Bi-Feng Liu
Public health events caused by pathogens have imposed significant economic and societal burdens. However, conventional methods still face challenges including complex operations, the need for trained operators, and sophisticated instruments. Here, we proposed a fully integrated and automated centrifugal microfluidic chip, also termed IACMC, for point-of-care multiplexed molecular diagnostics by harnessing
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Theory of nanostructured sensors integrated in/on microneedles for diagnostics and therapy Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Marco Fratus, Muhammad A. Alam
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Flexible microfluidic co-recognition coupled with magnetic enrichment and silent SERS sensing for simultaneous analysis of bacteria in food Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Bingyang Huo, Ling Xia, Yuling Hu, Gongke Li
Food safety represents a critical global public health issue, with safety challenges posed by foodborne pathogens garnering extensive attention. Therefore, we introduce a co-recognition, enrichment and sensing (CES) all-in-one strategy for analysis of bacteria with low background and high specificity. This method employs antimicrobial peptide (AMP) functionalized magnetic nanoparticles (MNPs) to enrich
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Light-driven, bias-free nitrogenase-based bioelectrochemical cell for ammonia generation Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-27 Matan M. Meirovich, Oren Bachar, Mor Shemesh, Yifat Cohen, Alice Popik, Omer Yehezkeli
Nitrogen fixation is a key process that sustains life on Earth. Nitrogenase is the sole enzyme capable of fixing nitrogen under ambient conditions. Extensive research efforts have been dedicated to elucidating the enzyme mechanism and its artificial activation through high applied voltage, photochemistry, or strong reducing agents. Harnessing light irradiation to minimize the required external bias
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Nonwoven fiber meshes for oxygen sensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-27 Nikolaos Salaris, Wenqing Chen, Paul Haigh, Lorenzo Caciolli, Giovanni Giuseppe Giobbe, Paolo De Coppi, Ioannis Papakonstantinou, Manish K. Tiwari
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Development of a selective electrochemical microsensor based on molecularly imprinted polydopamine/ZIF-67/laser-induced graphene for point-of-care determination of 3-nitrotyrosine Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-26 Chibin Zheng, Ruwei Liu, Jianyue Chen, Shilin Li, Yunhan Ling, Zhengjun Zhang
3-nitrotyrosine (3-NT) is a biomarker closely associated with the early diagnosis of oxidative stress-related disorders. The development of an accurate, cost-effective, point-of-care 3-NT sensor holds significant importance for self-monitoring and clinical treatment. In this study, a selective, sensitive, and portable molecularly imprinted electrochemical sensor was developed. ZIF-67 with strong adsorption
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Bacterial detection based on Förster resonance energy transfer Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-26 Wanqing Zhang, Weiqiang Li, Yang Song, Qian Xu, Hengyi Xu
The huge economic loss and threat to human health caused by bacterial infection have attracted the public's concern, and there is an urgent need to relieve and improve the tough problem. Therefore, it is significant to establish a facile, rapid, and sensitive method for bacterial detection considering the shortcomings of existing methods. Förster resonance energy transfer (FRET)-based sensors have
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Improving trans-cleavage activity of CRISPR-Cas13a using engineered crRNA with a uridinylate-rich 5′-overhang Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-25 Yihan Yang, Lingli Sun, Jianhong Zhao, Yang Jiao, Taoli Han, Xiaohong Zhou
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An ingestible near-infrared fluorescence capsule endoscopy for specific gastrointestinal diagnoses Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-24 Cheng Zhou, Jinlei Jiang, Songwei Huang, Junhao Wang, Xinyuan Cui, Weicheng Wang, Mingrui Chen, Jiawei Peng, Nanqing Shi, Bensong Wang, Amin Zhang, Qian Zhang, Qichao Li, Shengsheng Cui, Shenghao Xue, Wei Wang, Ning Tang, Daxiang Cui
Early diagnosis of gastrointestinal (GI) diseases is important to effectively prevent carcinogenesis. Capsule endoscopy (CE) can address the pain caused by wired endoscopy in GI diagnosis. However, existing CE approaches have difficulty effectively diagnosing lesions that do not exhibit obvious morphological changes. In addition, the current CE cannot achieve wireless energy supply and attitude control
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Recent advances towards point-of-care devices for fungal detection: Emphasizing the role of plasmonic nanomaterials in current and future technologies Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-24 Daria Stoia, Luciano De Sio, Francesca Petronella, Monica Focsan
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An electrochemical genomagnetic assay for detection of SARS-CoV-2 and Influenza A viruses in saliva Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-24 Daniel Júnior Almeida dos Santos, Tássia Regina de Oliveira, Gabriela Martins de Araújo, Henrique Pott-Junior, Matias Eliseo Melendez, Ester Cerdeira Sabino, Oldair Donizeti Leite, Ronaldo Censi Faria
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A sensitivity-enhanced plasmonic sensing platform modified with Co(OH)2 nanosheets Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-24 Yanpei Xu, Haoyu Wu, Meng Sun, Hongyu Song, Chuxiao Sun, Fudong Jia, Qi Wang
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Corrigendum to “Entrapment of uropathogenic E. coli cells into ultra-thin sol-gel matrices on gold thin films: A low cost alternative for impedimetric bacteria sensing” [Biosens Bioelectron. 124-125 (2019) 161-166 DOI: 10.1016/j.bios.2018.10.029] Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-23 Hamed Jafari, Mandana Amiri, Esmat Abdi, Saeid Latifi Navid, Julie Bouckaert, Roxana Jijie, Rabah Boukherroub, Sabine Szunerits
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Dual-plasmonic CuS@Au heterojunctions synergistic enhanced photothermal and colorimetric dual signal for sensitive multiplexed LFIA Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-22 Rui Shu, Sijie Liu, Meilin Wang, Mingrui Zhang, Biao Wang, Kexin Wang, Ibrahim A. Darwish, Jianlong Wang, Daohong Zhang
Multiplexed immunodetection, which achieves qualitative and quantitative outcomes for multiple targets in a single-run process, provides more sufficient results to guarantee food safety. Especially, lateral flow immunoassay (LFIA), with the ability to offer multiple test lines for analytes and one control line for verification, is a forceful candidate in multiplexed immunodetection. Nevertheless, given
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The 2.5th generation enzymatic sensors based on the construction of quasi-direct electron transfer type NAD(P)-Dependent dehydrogenases Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-22 Kurea Ikegai, Junko Okuda-Shimazaki, Truc Thanh Tran, Mika Hatada, Ryutaro Asano, Kazunori Ikebukuro, Wakako Tsugawa, Koji Sode
We introduce a versatile method to convert NAD or NADP -dependent dehydrogenases into quasi-direct electron transfer (quasi-DET)-type dehydrogenases, by modifying with a mediator on the enzyme surface toward the development of 2.5 generation enzymatic sensors. In this study, we use β-hydroxybutyrate (BHB) dehydrogenase (BHBDh) from (AfBHBDh) as a representative NAD or NADP -dependent dehydrogenase
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Inhibition of kinetic random-distribution in DNA Seesaw gates and biosensors for complete leakage prevention Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-22 Yang Qin, Feiyang Huang, Qi Tang, Jiangtian Li, Heao Zhang, Kuangdi Luo, Jiahui Zhou, Hongxun Wang, Limei Wang, Longjie Li, Xianjin Xiao
DNA nanomaterials have a wide application prospect in biomedical field, among which DNA computers and biosensors based on Seesaw-based DNA circuit is considered to have the most development potential. However, the serious leakage of Seesaw-based DNA circuit prevented its further development and application. Moreover, the existing methods to suppress leakage can't achieve the ideal effect. Interestingly
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Electrochemiluminescence biosensor for specific detection of pancreatic ductal carcinoma through dual targeting of MUC1 and miRNA-196a Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-22 Yuxuan Chen, Zhuoxin Ye, Mo Ma, Jukun Yang, Ruiyan Liu, Yan Zhang, Pinyi Ma, Daqian Song
Pancreatic ductal adenocarcinoma (PDAC) poses significant diagnostic challenges due to its asymptomatic nature in its early stages, low specificity of conventional assays, and limited efficacy of surgical interventions. However, clinical specificity of the current serum biomarkers is suboptimal, leading to diagnostic inaccuracies and oversights. Therefore, this study introduced a novel dual-target
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Mass-manufacturable scintillation-based optical fiber dosimeters for brachytherapy Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-21 Agnieszka Gierej, Tigran Baghdasaryan, Michael Martyn, Peter Woulfe, Owen Mc Laughlin, Kevin Prise, Geraldine Workman, Sinead O'Keeffe, Kurt Rochlitz, Sergey Verlinski, Agnese Giaz, Romualdo Santoro, Massimo Caccia, Francis Berghmans, Jürgen Van Erps
Scintillation-based fiber dosimeters are a powerful tool for minimally invasive localized real-time monitoring of the dose rate during Low Dose Rate (LDR) and High Dose Rate (HDR) brachytherapy (BT). This paper presents the design, fabrication, and characterization of such dosimeters, consisting of scintillating sensor tips attached to polymer optical fiber (POF). The sensor tips consist of inorganic
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Highly sensitive detection of the neurodegenerative biomarker Tau by using the concentration effect of the pyro-electrohydrodynamic jetting Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-21 Concetta Di Natale, Sara Coppola, Veronica Vespini, Volodymyr Tkachenko, Simone Russo, Giuseppina Luciani, Giuseppe Vitiello, Francesca Ferranti, Silvia Mari, Pietro Ferraro, Pier Luca Maffettone, Simonetta Grilli
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β-Galactosidase-activated near-infrared AIEgen for ovarian cancer imaging in vivo Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-20 Lingling Xu, Hang Gao, Yu Deng, Xiaoyang Liu, Wenjun Zhan, Xianbao Sun, Jing-Juan Xu, Gaolin Liang
Near-infrared (NIR) aggregation induced-emission luminogens (AIEgens) circumvent the noisome aggregation-caused quenching (ACQ) effect in physiological milieu, thus holding high promise for real-time and sensitive imaging of biomarkers in vivo. β-Galactosidase (β-Gal) is a biomarker for primary ovarian carcinoma, but current AIEgens for β-Gal sensing display emissions in the visible region and have
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Automated and ultrasensitive point-of-care glycoprotein detection using boronate-affinity enhanced organic electrochemical transistor patch Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-19 Jing Chen, Deqi Yang, Guoqi Zhu, Ru Zhang, Bingfang Wang, Zhiqiang Chang, Jing Dai, Wenjuan Wu, Menahem Y. Rotenberg, Yin Fang
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Electrochemical biosensing platform based on AuNWs/rGO-CMC-PEDOT:PSS composite for the detection of superoxide anion released from living cells Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-19 Renjun Jiang, Jiaojiao Liu, Xiaoqiang Liu, Jadranka Travas Sejdic
Detection of superoxide anion (O) levels holds significant importance for the diagnosis and even clinical treatments of oxidative stress-related diseases. Herein, we prepared a composite electrode material to encapsulate copper-zinc superoxide dismutase (SOD1) for biosensing of O. The sensing material consists of gold nanowires (AuNWs), reduced graphene oxide (rGO), carboxymethyl cellulose (CMC) and
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Peptide-based biosensing approaches for targeting breast cancer-derived exosomes Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-19 Rafael da Fonseca Alves, Arnau Pallarès-Rusiñol, Rosanna Rossi, Merce Martí, Emilia Rezende Vaz, Thaise Gonçalves de Araújo, Maria Del Pilar Taboada Sotomayor, Maria Isabel Pividori
Exosomes are nanovesicles present in all the biological fluids, making them attractive as non-invasive biomarkers for diseases like cancer, among many others. However, exosomes are complex to separate and detect, requiring comprehensive molecular characterization for their routine use in diagnostics. This study explores the use of peptides as cost-effective and stable alternatives to antibodies for
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Multifunctional fluorescence probe for simultaneous detection of viscosity, polarity, and ONOO− and its bioimaging in vitro and vivo Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-19 Yuan-Yuan Li, Jia-Ling Hu, Ji-Rou Wu, Yi-Ru Wang, Ai-Hong Zhang, Yu-Wei Tan, Ya-Jing Shang, Ting Liang, Min Li, Ya-Li Meng, Yan-Fei Kang
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Monitoring the electroactive cargo of extracellular vesicles can differentiate various cancer cell lines Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-19 Chloe L. Miller, Mareike Herrmann, David R.F. Carter, Nicholas Turner, Priya Samuel, Bhavik Anil Patel
Extracellular vesicles (EVs) are pivotal in cell-to-cell communication due to the array of cargo contained within these vesicles. EVs are considered important biomarkers for identification of disease, however most measurement approaches have focused on monitoring specific surface macromolecular targets. Our study focuses on exploring the electroactive component present within cargo from EVs obtained
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Advancements in optical fiber-based wearable sensors for smart health monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-18 Rajan Jha, Pratik Mishra, Santosh Kumar
Healthcare system is undergoing a significant transformation from a traditional hospital-centered to an individual-centered one, as a result of escalating chronic diseases, ageing populations, and ever-increasing healthcare costs,. Wearable sensors have become widely used in health monitoring systems since the COVID-19 pandemic. They enable continuous measurement of important health indicators like
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Long-term stable pH sensor array with synergistic bilayer structure for 2D real-time mapping in cell culture monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-18 Jimin Lee, Ira Soltis, Sayre A. Tillery, Sung Hoon Lee, Hodam Kim, Woon-Hong Yeo
Pursuing accurate, swift, and durable pH sensors is important across numerous fields, encompassing healthcare, environmental surveillance, and agriculture. In particular, the emphasis on real-time pH monitoring during cell cultivation has become increasingly pronounced in the current scientific environment—a crucial element being diligently researched to ensure optimal cell production. Both polyaniline