样式: 排序: IF: - GO 导出 标记为已读
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Recent developments in the enzymatic modifications of steroid scaffolds Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-16 Huibin Wang, Ikuro Abe
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Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-16 Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. Falconer
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Cu(OTf)2/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-15 Srinivasarao Yaragorla, Tabassum Khan, Sayonika Chakroborty
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Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-16 Shigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi Nishida
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BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-16 Gaurav Jaiswal, Subhas Chandra Pan
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Charge-transfer inclusion complex formation of the tropylium cation with prism[6]arenes Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-12 Guojiao Zhang, Channi Cheng, Zhengxiang Li, Dezhi Zhao, Chengyou Han
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Total synthesis of diplofuranone A and diapolic acid A Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-16 Dattatraya H. Dethe, Vimlesh Kumar, Nagabhushana C. Beeralingappa
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Catalyst- and base-free visible light-enabled radical relay trihalomethylation/functional group-migration/carbonylation with CX3SO2Cl Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-16 Jinkai Hu, Chenglei Yang, Xiaotao Qin, Hui Liu, Tongtong Ma, Ao-tong Shi, Qing-Long Lv, Xingman Liu, Jinhui Yang, Dianjun Li
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Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-15 Dongyu Tang, Yaqing Ma, Jinping Bao, Shushan Gao, Shuli Man, Chengsen Cui
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Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-10 Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari
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Correction: Recent progress of core-substituted naphthalenediimides: highlights from 2010 Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-12 Sheshanath V. Bhosale, Sidhanath V. Bhosale, Suresh K. Bhargava
Correction for ‘Recent progress of core-substituted naphthalenediimides: highlights from 2010’ by Sheshanath V. Bhosale et al., Org. Biomol. Chem., 2012, 10, 6455–6468, https://doi.org/10.1039/C2OB25798J.
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Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-12 Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-11 Michela Eleuteri, Jenny Desantis, Gabriele Cruciani, Raimondo Germani, Laura Goracci
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Photochromism of phenazine-2,3-diol derivatives through excited state intermolecular proton transfer based on keto–enol tautomerization Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-11 Kazuki Ohira, Kumpei Kozuka, Naoki Kaneda, Masahiro Yamamoto, Keiichi Imato, Yousuke Ooyama
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On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-10 Julia A. Turner, Hendrik Zipse, Mark S. Taylor
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Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-10 Yuma Matsuura, Shinichiro Fuse
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Kinetic resolution of 1,1′-binaphthyl-2,2′-diamine derivatives by chiral calcium phosphate-catalyzed acylation Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-06 Tatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama
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3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-10 Alexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov
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Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-10 Tatiana P. Gerasimova, Almaz A. Zagidullin, Anastasiia N. Nikolaeva, Robert R. Fayzullin, Aliya M. Saitova, Vasili A. Miluykov, Stefan Grimme, Sergey A. Katsyuba
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Asymmetric total synthesis of humulane sesquiterpenoids alashanoids B, C, E, and F and 2,9-humuladien-6-ol-8-one Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-10 Rasmita Barik, Samik Nanda
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Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-10 Fuxin Li, Hui Liu, Wanyu Xing, Qingju Zhang, Liming Wang
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Metal- and light-free decarboxylative direct C–H alkylation of heteroarenes at room temperature Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-04 Tong-Bo Zhang, Xi-Dong Guan, Yan Gao, Shi-Chao Lu, Bing-Long Li
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Friedel–Crafts reactions for biomolecular chemistry Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-09 Jun Ohata
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Copper-catalyzed ortho-thiocyanation of aromatic amines Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-09 Monak Patel, Nitish Kumar, Hussain Bhukya, Bharatkumar Z. Dholakiya, Togati Naveen
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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-09 Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
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DFT investigation of the DDQ-catalytic mechanism for constructing C–O bonds Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-09 Xiu-Fang Zheng, Da-Gang Zhou, Li-Jun Yang
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A copper-catalyzed asymmetric Friedel–Crafts hydroxyalkylation of pyrazole-4,5-diones with 5-aminoisoxazoles Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-09 Siyu Gao, Xiang Sun, Sijie Peng, Zhenggen Zha, Qi Sun, Zhiyong Wang
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Synthesis of alkenylphosphine oxides via Tf2O promoted addition–elimination of ketones and secondary phosphine oxides Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-09 Jiangkai Ma, Lianjie Wang, Anjiang Qiao, Zhongxian Li, Fengqian Zhao, Junliang Wu
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Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-08 Wen-Jie Li, Jun-You Chen, Hui-Xia Zhu, Yi-Ming Li, Yang Xu
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Siloxane-containing phosphine (oxide) ligands for enhanced catalytic activity of cobalt complexes for hydrosilylation reactions Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-03 Peng Liu, Jiajian Peng, Ying Bai, Jiayun Li
A series of siloxane-containing phosphine (oxide) ligands have been designed and synthesized. These phosphine (oxide) ligands contain silicon atoms, which can impart better solubility in the relevant media, thereby improving certain catalytic performances. The hydrosilylation of olefins catalyzed by these metal phosphine (oxide) complexes has been conducted under mild reaction conditions.
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Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-02 Muhammad Ehtisham Ibraheem Khan, Tomas Lighuen Cassini, Marino Petrini, Alessandro Palmieri
β-Nitroenones can be efficiently converted into 3,5-disubstituted isoxazoles by using tin(II)chloride dihydrate and ethyl acetate as a reducing agent and solvent, respectively. Products are obtained in good yields and several functional groups are tolerated thanks to the mild reaction conditions.
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Fine bubble technology for the green synthesis of fairy chemicals Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-02 Arun Kumar Manna, Mizuki Doi, Keiya Matsuo, Hiroto Sakurai, Ch. Subrahmanyam, Kohei Sato, Tetsuo Narumi, Nobuyuki Mase
Fairy chemicals (FCs), such as 2-azahypoxanthine (AHX), are a potential new class of plant hormones that are naturally present in plants and produced via a novel purine metabolic pathway. FCs support plant resilience against various stresses and regulate plant growth. In this study, we developed a four-step method for synthesising AHX from 2-cyanoacetamide, achieving a good yield. Oxime was obtained
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Electrochemical selective divergent C–H chalcogenocyanation of N-heterocyclic scaffolds Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-01 Kusum Ucheniya, Pooja Kumari Jat, Amreen Chouhan, Lalit Yadav, Satpal Singh Badsara
An electrochemical direct selective C–H chalcogenocyanation approach for indolizine derivatives under mild conditions has been described. Cyclic enone-fused, chromone-fused and 2-substituted indolizines possessing EDGs (electron donating groups) and EWGs (electron withdrawing groups) were successfully reacted with NH4SCN and KSeCN under electrochemical conditions to provide a wide array of mono and
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Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-05 Yixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu Yang
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HFIP-mediated C-3-alkylation of indoles and synthesis of indolo[2,3-b]quinolines & related natural products Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-05 Auqib Rashid, Waseem I. Lone, Preeti Dogra, Showkat Rashid, Bilal A. Bhat
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A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-05 Yinsong Wu, Guanghao Shi, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Xiaobing Wu, Yongjia Shang, Xinwei He
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Electrochemical and photochemical reaction of isatins: a decade update Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-05 Nandini M. Gotgi, J. Saurab Jain, Rita Pal, Debashis Ghosh
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-05 Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
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Deconstructive annulation mediated one-pot synthesis of xanthene derivatives Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-04 Balasubramaniyam Manikandan, Subbiah Thamotharan, Olivier Blacque, Subramaniapillai Selva Ganesan
Direct conversion of naphthoxazines to diverse xanthene derivatives was achieved under one-pot operation through deconstructive annulation methodology. Sequential oxidative C(sp3)–O/C(sp3)–N cleavage followed by intramolecular/intermolecular annulation reaction was carried out under aerobic reaction conditions. Mechanistic analyses performed on the substrate revealed that the C(sp3)–O bond cleavage
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Palladium-catalyzed C–C bond cleavage of N-cyclopropyl acylhydrazones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-01 Hiroki Fujioka, Motohiro Yasui, Shohei Hamada, Kohei Fukumi, Norihiko Takeda, Yusuke Kobayashi, Takumi Furuta, Masafumi Ueda
Despite their utility as directing groups, the C–C bond cleavage of cyclopropanes utilizing hydrazones has not been explored. Herein, Pd-catalyzed C–C bond cleavage reaction of N-cyclopropyl acylhydrazones, followed by cycloisomerization to yield pyrazoles, has been developed. The protocol enables the synthesis of various α-pyrazole carbonyl compounds, which have a potential of biological activity
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An efficient synthesis of mono-, di-, and tri-substituted 1,3-thiazoles employing functionalized thioamides as thiocarbonyl precursors Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-04 Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Krishna Ravi Singh, Kalleshappa Sharath, Maralinganadoddi P. Sadashiva
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-04 Debojyoti Bag, Sanghapal D. Sawant
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Ru–Mg promoted reductive cross-coupling of allyl bromides and alkenes to synthesize 1,7-octadienes with an all-carbon quaternary center Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-29 Shurong Zhang, Xinjie Zhao, Guiping Qin
A Ru-promoted reductive cross-coupling of allyl bromides and electron-deficient alkenes to provide terminal 1,7-octadienes with magnesium as a reductant is reported herein. This approach enables the facile construction of a series of complex terminal 1,7-octadienes with an all-carbon quaternary center under mild reaction conditions, and the synthetic utility of the current method has been demonstrated
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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-03 Debasish Bera, Rajib Sarkar, Tiyasa Dhar, Pinaki Saha, Prasanta Ghosh, Chhanda Mukhopadhyay
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Dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-03 Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni, Long Chen
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Photoinduced decatungstate-catalyzed C(sp3)–H thioetherification by sulfinate salts Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-03 Pengcheng Li, Jia-Lin Tu, Ao-Men Hu, Lin Guo, Chao Yang, Wujiong Xia
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Iodomethane in C1 chemistry: application in palladium-catalyzed [2 + 2 + 1] annulation Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-02 Jin-Ke Zhang, Yu-Chen Fang, Jia-He Chen, Jing Shan, Mei Bai, Qiang Huang, Yong-Zheng Chen, Wen-Yong Han
An efficient palladium-catalyzed [2 + 2 + 1] annulation of 3-iodochromones, bridged olefins, and iodomethane is described, affording a range of chromone-containing polycyclic compounds. Additionally, the corresponding deuterated products were smoothly obtained with iodomethane-d3 instead of iodomethane. Moreover, the synthetic utility of this method is further substantiated by gram scale preparation
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Stereodivergent synthesis of 2-oxo-oligopyrrolidines by an iterative coupling strategy Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-28 Yasuki Soda, Kumpei Tatsumi, Matteo Forner, Shunsei Sato, Kana Shibuya, Tomoe Matagawa, Siro Simizu, Noritaka Chida, Toshitaka Okamura, Takaaki Sato
Natural linear polyamines play diverse roles in physiological processes by interacting with receptors at the cellular level. Herein, we describe the stereodivergent synthesis of oligopyrrolidines, which are conformationally constrained polyamines. We synthesized dimeric and trimeric 2-oxo-oligopyrrolidines using an iterative coupling strategy. The key to our success is an iridium-catalyzed trans/cis-selective
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BODIPY(aryl)iodonium salts in the efficient synthesis of diversely functionalized BODIPYs and selective detection of serum albumin Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-02 Bintu Kumar, Anindita Bhatta, Prakriti Saraf, Taur Prakash Pandurang, Krishnan Rangan, Madhushree Sarkar, Sivaprasad Mitra, Dalip Kumar
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-02 Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
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New 2-pyridone-based donor–acceptor dyes: the effect of the donor group position, type of π-linker and acid–base characteristics of the medium on the photophysical properties Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-02 Saveliy P. Sorokin, Mikhail Yu. Ievlev, Oleg V. Ershov
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Click synthesis of dendronized malonates for the preparation of amphiphilic dendro[60]fullerenes Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-01 Carlos Cruz-Hernández, Perla Y. López-Camacho, Gustavo Basurto-Islas, Aaron Rojas, Patricia Guadarrama, Melchor Martínez-Herrera
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Catalytic asymmetric construction of helicenes via transformation of biaryls Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-04-01 Peiling Fan, Lun Li, Deyun Qian
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Pd-catalyzed three-component [2 + 2 + 1] cycloamination toward carbazoles Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-29 Mingzhu Shen, Min Li, Jingxun Yu
Conventional approaches using hydroxylamine derivatives as single nitrogen sources for the preparation of N-heterocyclic molecules rely on two chemical processes involving sequential nucleophilic and electrophilic C–N bond formations. Herein, we report a novel Suzuki reaction/C–H activation/amination sequence for building a myriad of carbazoles in a single transformation using bifunctional secondary
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Zirconium oxide nano-catalyzed synthesis of pharmacologically important bis(indolyl)methanes: a highly efficient and mild approach Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-28 Komal Rathi, Om Shanker Tiwari, Varun Rawat, Jawahar L. Jat, Dinesh Kumar Yadav, Ved Prakash Verma
We report herein a highly efficient and mild approach for synthesizing pharmacologically active bis(indolyl)methanes 3a–z, utilizing ZrO2 nanoparticles as a catalyst. The method involves a condensation reaction between indole and diverse aromatic aldehydes in acetonitrile under mild conditions. The ZrO2 nano-catalyst prepared via a co-precipitation method demonstrates exceptional efficacy, leading
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A formal vinylic substitution reaction for the synthesis of α,β-unsaturated enol esters and their anticancer potential Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-28 Bhawna Swami, Neetu Kumari, Mulaka Maruthi, Neethu K. Kunjunny, Rajeev S. Menon
Arylsulfonyl group-bearing α,β-unsaturated enol esters were readily assembled via the Cs2CO3-mediated union of 2-bromoallyl sulfones and cinnamic acids. The overall transformation is equivalent to an sp2 carbon–oxygen coupling reaction, and therefore constitutes a formal vinylic substitution. Several of the products display promising levels of antiproliferative activities higher than that of the anticancer
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Visible-light-promoted regioselective hydrocarboxylation of allenes with formate salt and CO2 Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-28 Xian-Ming Zhang, Bao-En Liu, Zhen-Qiang Zhang, Zhuang-Ping Zhan
Visible-light-promoted hydrocarboxylation of allenes with formate salt and CO2 was developed for the first time using commercially available [Ir(ppy)2(dtbbpy)]PF6 as a photocatalyst. This strategy provides an efficient and practical method to access β,γ-unsaturated linear carboxylic acids in moderate yields with complete regioselectivity.
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Direct access to pyrrole anhydrides via oxidative self-coupling of pyrrole carboxaldehydes Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-27 Surabhi Panday, Tapas Maity, Pratibha Bhatti, Joydev K. Laha
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Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-25 Matthew Nutter, Henry Stone, Michael Shipman, Stefan Roesner
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Iron-catalyzed selective construction of indole derivatives via oxidative C(sp3)–H functionalization of indolin-2-ones Org. Biomol. Chem. (IF 3.2) Pub Date : 2024-03-27 Wei Chen, Lang-Qi Wen, Xiao-Bing Lu, Hui Zhou
Considering the importance of developing powerful catalysts and the pharmacophore characteristics of indole derivatives, we describe a switchable approach for the iron-catalyzed oxidative C(sp3)–H functionalization of indolin-2-ones. Selective transformations displayed excellent activity and chemoselectivity using FeCl2 as the catalyst, air as the oxidant, and alcohol as the solvent. By manipulating