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The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA Dev. Cell (IF 11.8) Pub Date : 2024-03-13 Shijia Bi, Xiaoyu Jiang, Qianzhao Ji, Zehua Wang, Jie Ren, Si Wang, Yang Yu, Ruoqi Wang, Zunpeng Liu, Junhang Liu, Jianli Hu, Guoqiang Sun, Zeming Wu, Zhiqing Diao, Jingyi Li, Liang Sun, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Guang-Hui Liu, Jing Qu
Sirtuins are pro-longevity genes with chromatin modulation potential, but how these properties are connected is not well understood. Here, we generated a panel of isogeneic human stem cell lines with SIRT1–SIRT7 knockouts and found that any sirtuin deficiency leads to accelerated cellular senescence. Through large-scale epigenomic analyses, we show how sirtuin deficiency alters genome organization
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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon Dev. Cell (IF 11.8) Pub Date : 2024-03-06 Chinmoy Ghosh, Ruchi Kakar, Rosalie G. Hoyle, Zheng Liu, Chunqing Guo, Jiong Li, Xiang-Yang Wang, Yue Sun
The interferon signaling pathway is critical for host defense by serving diverse functions in both innate and adaptive immune responses. Here, we show that type I gamma phosphatidylinositol phosphate 5-kinase i5 (PIPKIγi5), an enzyme that synthesizes phosphatidylinositol-4,5-bisphosphate (PI4,5P), controls the sensitivity to interferon in both human and mouse cells. PIPKIγi5 directly binds to the interferon-gamma
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Rim aperture of yeast autophagic membranes balances cargo inclusion with vesicle maturation Dev. Cell (IF 11.8) Pub Date : 2024-03-05 Oren Shatz, Milana Fraiberg, Damilola Isola, Shubhankar Das, Olee Gogoi, Alexandra Polyansky, Eyal Shimoni, Tali Dadosh, Nili Dezorella, Sharon G. Wolf, Zvulun Elazar
Autophagy eliminates cytoplasmic material by engulfment in membranous vesicles targeted for lysosome degradation. Nonselective autophagy coordinates sequestration of bulk cargo with the growth of the isolation membrane (IM) in a yet-unknown manner. Here, we show that in the budding yeast , IMs expand while maintaining a rim sufficiently wide for sequestration of large cargo but tight enough to mature
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ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation Dev. Cell (IF 11.8) Pub Date : 2024-02-21 Sheng Li, Jin Sun, Bo-Wen Zhang, Lu Yang, Ying-Cui Wan, Bei-Bei Chen, Nan Xu, Qian-Ru Xu, Juan Fan, Jia-Ni Shang, Rui Li, Chen-Ge Yu, Yan Xi, Su Chen
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Aberrant cortex contractions impact mammalian oocyte quality Dev. Cell (IF 11.8) Pub Date : 2024-02-21 Elvira Nikalayevich, Gaëlle Letort, Ghislain de Labbey, Elena Todisco, Anastasia Shihabi, Hervé Turlier, Raphaël Voituriez, Mohamed Yahiatene, Xavier Pollet-Villard, Metello Innocenti, Melina Schuh, Marie-Emilie Terret, Marie-Hélène Verlhac
The cortex controls cell shape. In mouse oocytes, the cortex thickens in an Arp2/3-complex-dependent manner, ensuring chromosome positioning and segregation. Surprisingly, we identify that mouse oocytes lacking the Arp2/3 complex undergo cortical actin remodeling upon division, followed by cortical contractions that are unprecedented in mammalian oocytes. Using genetics, imaging, and machine learning
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Stem cell migration drives lung repair in living mice Dev. Cell (IF 11.8) Pub Date : 2024-02-19 Maurizio Chioccioli, Shuyu Liu, Sumner Magruder, Aleksandra Tata, Lucia Borriello, John E. McDonough, Arvind Konkimalla, Sang-Hun Kim, Jessica Nouws, David G. Gonzalez, Brian Traub, Xianjun Ye, Tao Yang, David R. Entenberg, Smita Krishnaswamy, Caroline E. Hendry, Naftali Kaminski, Purushothama Rao Tata, Maor Sauler
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A metabolically controlled contact site between vacuoles and lipid droplets in yeast Dev. Cell (IF 11.8) Pub Date : 2024-02-16 Duy Trong Vien Diep, Javier Collado, Marie Hugenroth, Rebecca Martina Fausten, Louis Percifull, Mike Wälte, Christian Schuberth, Oliver Schmidt, Rubén Fernández-Busnadiego, Maria Bohnert
The lipid droplet (LD) organization proteins Ldo16 and Ldo45 affect multiple aspects of LD biology in yeast. They are linked to the LD biogenesis machinery seipin, and their loss causes defects in LD positioning, protein targeting, and breakdown. However, their molecular roles remained enigmatic. Here, we report that Ldo16/45 form a tether complex with Vac8 to create vacuole lipid droplet (vCLIP) contact
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SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway Dev. Cell (IF 11.8) Pub Date : 2024-02-15 Vicky W.T. Tan, Talhah M. Salmi, Anthony P. Karamalakis, Andrea Gillespie, Athena Jessica S. Ong, Jesse J. Balic, Yih-Chih Chan, Cerys E. Bladen, Kristin K. Brown, Mark A. Dawson, Andrew G. Cox
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Gibberellic acid promotes single-celled fiber elongation through the activation of two signaling cascades in cotton Dev. Cell (IF 11.8) Pub Date : 2024-02-14 Peng He, Liping Zhu, Xin Zhou, Xuan Fu, Yu Zhang, Peng Zhao, Bin Jiang, Huiqin Wang, Guanghui Xiao
The agricultural green revolution spectacularly enhanced crop yield through modification of gibberellin (GA) signaling. However, in cotton, the GA signaling cascades remain elusive, limiting our potential to cultivate new cotton varieties and improve yield and quality. Here, we identified that GA prominently stimulated fiber elongation through the degradation of DELLA protein GhSLR1, thereby disabling
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Determining the potency of primordial germ cells by injection into early mouse embryos Dev. Cell (IF 11.8) Pub Date : 2024-02-14 Lessly P. Sepulveda-Rincon, Yi-Fang Wang, Chad Whilding, Benjamin Moyon, Obah A. Ojarikre, Valdone Maciulyte, Nobuhiko Hamazaki, Katsuhiko Hayashi, James M.A. Turner, Harry G. Leitch
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Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms Dev. Cell (IF 11.8) Pub Date : 2024-02-14 Matthew J. Shannon, Gina L. McNeill, Burak Koksal, Jennet Baltayeva, Jasmin Wächter, Barbara Castellana, Maria S. Peñaherrera, Wendy P. Robinson, Peter C.K. Leung, Alexander G. Beristain
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Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells Dev. Cell (IF 11.8) Pub Date : 2024-02-14 Trieu Le, Iuliia Ferling, Lanhui Qiu, Clement Nabaile, Leonardo Assunção, Calvin D. Roskelley, Sergio Grinstein, Spencer A. Freeman
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Lineage motifs as developmental modules for control of cell type proportions Dev. Cell (IF 11.8) Pub Date : 2024-02-14 Martin Tran, Amjad Askary, Michael B. Elowitz
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The BAS chromatin remodeler determines brassinosteroid-induced transcriptional activation and plant growth in Arabidopsis Dev. Cell (IF 11.8) Pub Date : 2024-02-14 Tao Zhu, Chuangqi Wei, Yaoguang Yu, Zhenzhen Zhang, Jiameng Zhu, Zhenwei Liang, Xin Song, Wei Fu, Yuhai Cui, Zhi-Yong Wang, Chenlong Li
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Multimodal mass spectrometry imaging identifies cell-type-specific metabolic and lipidomic variation in the mammalian liver Dev. Cell (IF 11.8) Pub Date : 2024-02-14 Hua Tian, Presha Rajbhandari, Jay Tarolli, Aubrianna M. Decker, Taruna V. Neelakantan, Tina Angerer, Fereshteh Zandkarimi, Helen Remotti, Gilles Frache, Nicholas Winograd, Brent R. Stockwell
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LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced lipophagy in yeast Dev. Cell (IF 11.8) Pub Date : 2024-02-13 Irene Álvarez-Guerra, Emma Block, Filomena Broeskamp, Sonja Gabrijelčič, Terence Infant, Ana de Ory, Lukas Habernig, Claes Andréasson, Tim P. Levine, Johanna L. Höög, Sabrina Büttner
Lipid droplets (LDs) are fat storage organelles critical for energy and lipid metabolism. Upon nutrient exhaustion, cells consume LDs via gradual lipolysis or via lipophagy, the uptake of LDs into the vacuole. Here, we show that LDs dock to the vacuolar membrane via a contact site that is required for lipophagy in yeast. The LD-localized LDO proteins carry an intrinsically disordered region that directly
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Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm Dev. Cell (IF 11.8) Pub Date : 2024-02-13 Zhixuan Wu, Sophie Shen, Dalia Mizikovsky, Yuanzhao Cao, Marina Naval-Sanchez, Siew Zhuan Tan, Yanina D. Alvarez, Yuliangzi Sun, Xiaoli Chen, Qiongyi Zhao, Daniel Kim, Pengyi Yang, Timothy A. Hill, Alun Jones, David P. Fairlie, Alice Pébay, Alex W. Hewitt, Patrick P.L. Tam, Melanie D. White, Christian M. Nefzger, Nathan J. Palpant
Wnt signaling is a critical determinant of cell lineage development. This study used Wnt dose-dependent induction programs to gain insights into molecular regulation of stem cell differentiation. We performed single-cell RNA sequencing of hiPSCs responding to a dose escalation protocol with Wnt agonist CHIR-99021 during the exit from pluripotency to identify cell types and genetic activity driven by
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Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transition Dev. Cell (IF 11.8) Pub Date : 2024-02-09 John-Poul Ng-Blichfeldt, Benjamin J. Stewart, Menna R. Clatworthy, Julie M. Williams, Katja Röper
During kidney development, nephron epithelia arise from fate-committed mesenchymal progenitors through a mesenchymal-to-epithelial transition (MET). Downstream of fate specification, transcriptional mechanisms that drive establishment of epithelial morphology are poorly understood. We used human iPSC-derived renal organoids, which recapitulate nephrogenesis, to investigate mechanisms controlling renal
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Construction of single-cell cross-species chromatin accessibility landscapes with combinatorial-hybridization-based ATAC-seq Dev. Cell (IF 11.8) Pub Date : 2024-02-07 Guodong Zhang, Yuting Fu, Lei Yang, Fang Ye, Peijing Zhang, Shuang Zhang, Lifeng Ma, Jiaqi Li, Hanyu Wu, Xiaoping Han, Jingjing Wang, Guoji Guo
Despite recent advances in single-cell genomics, the lack of maps for single-cell candidate -regulatory elements (cCREs) in non-mammal species has limited our exploration of conserved regulatory programs across vertebrates and invertebrates. Here, we developed a combinatorial-hybridization-based method for single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) named CH-ATAC-seq
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A transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition Dev. Cell (IF 11.8) Pub Date : 2024-02-06 Yazhou Hao, Yihong Yang, Hui Tu, Zhonglong Guo, Pengcheng Chen, Xiaoting Chao, Ye Yuan, Zhimeng Wang, Xilin Miao, Songlin Zou, Dong Li, Yanzhi Yang, Congying Wu, Bo Li, Lei Li, Huaqing Cai
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Maternal KLF17 controls zygotic genome activation by acting as a messenger for RNA Pol II recruitment in mouse embryos Dev. Cell (IF 11.8) Pub Date : 2024-02-06 Yue Hu, Yuxiang Wang, Yuanlin He, Maosheng Ye, Jie Yuan, Chao Ren, Xia Wang, Siqi Wang, Yueshuai Guo, Qiqi Cao, Shuai Zhou, Bing Wang, Anlan He, Jiongsong Hu, Xuejiang Guo, Wenjie Shu, Ran Huo
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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors Dev. Cell (IF 11.8) Pub Date : 2024-02-05 Yuji Atsuta, ChangHee Lee, Alan R. Rodrigues, Charlotte Colle, Reiko R. Tomizawa, Ernesto G. Lujan, Patrick Tschopp, Laura Galan, Meng Zhu, Joshua M. Gorham, Jean-Pierre Vannier, Christine E. Seidman, Jonathan G. Seidman, Marian A. Ros, Olivier Pourquié, Clifford J. Tabin
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A phosphodiesterase pathway essential for lymphangiogenic growth arrest and maturation Dev. Cell (IF 11.8) Pub Date : 2024-02-05 Kari Alitalo
In developing embryos, downregulation of lymphatic endothelial proliferation is needed for maturation of lymphatic vessels into a hierarchical network. In this issue of Developmental Cell, Carlantoni discover that phosphodiesterase2A controls lymphatic endothelial growth arrest and maturation via regulation of cGMP, p38 MAP kinase, and Notch pathway.
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Aneuploidy-induced cellular behaviors: Insights from Drosophila Dev. Cell (IF 11.8) Pub Date : 2024-02-05 Jery Joy, Elena Fusari, Marco Milán
A balanced gene complement is crucial for proper cell function. Aneuploidy, the condition of having an imbalanced chromosome set, alters the stoichiometry of gene copy numbers and protein complexes and has dramatic consequences at the cellular and organismal levels. In humans, aneuploidy is associated with different pathological conditions including cancer, microcephaly, mental retardation, miscarriages
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Senescent cells and macrophages cooperate through a multi-kinase signaling network to promote intestinal transformation in Drosophila Dev. Cell (IF 11.8) Pub Date : 2024-02-02 Ishwaree Datta, Erdem Bangi
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Glia trigger endocytic clearance of axonal proteins to promote rodent myelination Dev. Cell (IF 11.8) Pub Date : 2024-02-02 Yoko Bekku, Brendan Zotter, Changjiang You, Jacob Piehler, Warren J. Leonard, James L. Salzer
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Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR Dev. Cell (IF 11.8) Pub Date : 2024-02-02 Kojiro Ishibashi, Toshiya Ichinose, Riki Kadokawa, Ryo Mizutani, Sadahiro Iwabuchi, Sumihito Togi, Hiroki Ura, Shoichiro Tange, Keiko Shinjo, Jun Nakayama, Shigeki Nanjo, Yo Niida, Yutaka Kondo, Shinichi Hashimoto, Erik Sahai, Seiji Yano, Mitsutoshi Nakada, Eishu Hirata
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Characterization of the human fetal gonad and reproductive tract by single-cell transcriptomics Dev. Cell (IF 11.8) Pub Date : 2024-01-30 Jasin Taelman, Sylwia M. Czukiewska, Ioannis Moustakas, Yolanda W. Chang, Sanne Hillenius, Talia van der Helm, Lotte E. van der Meeren, Hailiang Mei, Xueying Fan, Susana M. Chuva de Sousa Lopes
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The soil emergence-related transcription factor PIF3 controls root penetration by interacting with the receptor kinase FER Dev. Cell (IF 11.8) Pub Date : 2024-01-30 Fan Xu, Jia Chen, Yingbin Li, Shilin Ouyang, Mengting Yu, Yirong Wang, Xianming Fang, Kai He, Feng Yu
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PUF partner interactions at a conserved interface shape the RNA-binding landscape and cell fate in Caenorhabditis elegans Dev. Cell (IF 11.8) Pub Date : 2024-01-29 Brian H. Carrick, Sarah L. Crittenden, Fan Chen, MaryGrace Linsley, Jennifer Woodworth, Peggy Kroll-Conner, Ahlan S. Ferdous, Sündüz Keleş, Marvin Wickens, Judith Kimble
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A screen for regeneration-associated silencer regulatory elements in zebrafish Dev. Cell (IF 11.8) Pub Date : 2024-01-29 Kazunori Ando, Jianhong Ou, John D. Thompson, John Welsby, Sushant Bangru, Jingwen Shen, Xiaolin Wei, Yarui Diao, Kenneth D. Poss
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Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells Dev. Cell (IF 11.8) Pub Date : 2024-01-24 Wenxiu Dai, Zhixiong Liu, Minbiao Yan, Ximing Nian, Fan Hong, Zhihao Zhou, Chaomeng Wang, Xing Fu, Xuewen Li, Mengyun Jiang, Yanqin Zhu, Qiuying Huang, Xiaoyun Lu, Lichao Hou, Ning Yan, Qin Wang, Jin Hu, Wei Mo, Xueqin Zhang, Liang Zhang
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A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis Dev. Cell (IF 11.8) Pub Date : 2024-01-24 Ling-Li Wang, Yu-Zhuo Mai, Ming-Hua Zheng, Guang-Hai Yan, Jing-Yi Jin
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Blood and bones: Mechanical cues and Hippo signaling drive vascular invasion during limb formation Dev. Cell (IF 11.8) Pub Date : 2024-01-22 Marc N. Wein
Although mechanical cues are known to influence the postnatal skeleton, the impact of bone cell mechano-transduction on early skeletal development remains less clear. In this issue of Developmental Cell, Collins et al. (2023) report that YAP/TAZ deletion in osteoblast precursors reduces Cxcl12 expression, leading to defects in bone vascularization.
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Optimizing rice grain size by attenuating phosphorylation-triggered functional impairment of a chromatin modifier ternary complex Dev. Cell (IF 11.8) Pub Date : 2024-01-17 Shao-Yan Shen, Ming Ma, Chen Bai, Wei-Qing Wang, Rui-Bin Zhu, Qiong Gao, Xian-Jun Song
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ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1 Dev. Cell (IF 11.8) Pub Date : 2024-01-17 Xin Huang, Sophie Balmer, Cong Lyu, Yunlong Xiang, Vikas Malik, Hailin Wang, Yu Zhang, Bishuang Cai, Wei Xie, Anna-Katerina Hadjantonakis, Hongwei Zhou, Jianlong Wang
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Tissue-resident macrophages specifically express Lactotransferrin and Vegfc during ear pinna regeneration in spiny mice Dev. Cell (IF 11.8) Pub Date : 2024-01-15 Jennifer Simkin, Ajoy Aloysius, Mike Adam, Fatemeh Safaee, Renée R. Donahue, Shishir Biswas, Zohaib Lakhani, John C. Gensel, David Thybert, Steven Potter, Ashley W. Seifert
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Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner Dev. Cell (IF 11.8) Pub Date : 2024-01-17 Jean-Francois Darrigrand, Anna Salowka, Alejo Torres-Cano, Rafael Tapia-Rojo, Tong Zhu, Sergi Garcia-Manyes, Francesca M. Spagnoli
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Distinct epicardial gene regulatory programs drive development and regeneration of the zebrafish heart Dev. Cell (IF 11.8) Pub Date : 2024-01-17 Michael Weinberger, Filipa C. Simões, Trishalee Gungoosingh, Tatjana Sauka-Spengler, Paul R. Riley
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Live-cell imaging defines a threshold in CDK activity at the G2/M transition Dev. Cell (IF 11.8) Pub Date : 2024-01-15 Hironori Sugiyama, Yuhei Goto, Yohei Kondo, Damien Coudreuse, Kazuhiro Aoki
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A mechanical wave travels along a genetic guide to drive the formation of an epithelial furrow during Drosophila gastrulation Dev. Cell (IF 11.8) Pub Date : 2024-01-15 Anna Popkova, Urška Andrenšek, Sophie Pagnotta, Primož Ziherl, Matej Krajnc, Matteo Rauzi
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PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression Dev. Cell (IF 11.8) Pub Date : 2024-01-15 Annachiara Del Vecchio, Patrizia Mulé, Daniel Fernández-Pérez, Simona Amato, Georgia Lattanzi, Marika Zanotti, Samantha Rustichelli, Silvia Pivetti, Paola Oldani, Andrea Mariani, Fabiola Iommazzo, Haruhiko Koseki, Federica Facciotti, Simone Tamburri, Karin J. Ferrari, Diego Pasini
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Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration Dev. Cell (IF 11.8) Pub Date : 2024-01-09 Juan Wang, Dong-Lin Li, Lang-Fan Zheng, Su Ren, Zi-Qin Huang, Ying Tao, Ziyu Liu, Yanxia Shang, Dejian Pang, Huiling Guo, Taoling Zeng, Hong-Rui Wang, He Huang, Xingrong Du, Haobin Ye, Hai-Meng Zhou, Peng Li, Tong-Jin Zhao
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Understanding the cell fate and behavior of progenitors at the origin of the mouse cardiac mitral valve Dev. Cell (IF 11.8) Pub Date : 2024-01-09 Batoul Farhat, Ignacio Bordeu, Bernd Jagla, Stéphanie Ibrahim, Sonia Stefanovic, Hugo Blanc, Karine Loulier, Benjamin D. Simons, Emmanuel Beaurepaire, Jean Livet, Michel Pucéat
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Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis Dev. Cell (IF 11.8) Pub Date : 2024-01-09 Eun Kyung Ko, Amy Anderson, Carina D’souza, Jonathan Zou, Sijia Huang, Sohyun Cho, Faizan Alawi, Stephen Prouty, Vivian Lee, Sora Yoon, Keegan Krick, Yoko Horiuchi, Kai Ge, John T. Seykora, Brian C. Capell
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Defining the fate trajectory of eccrine gland formation Dev. Cell (IF 11.8) Pub Date : 2024-01-08 Meagan C. Branch, Elena Ezhkova
Eccrine glands secrete water onto the surface of human skin to regulate body temperature. In this issue of Developmental Cell, Dingwall et al. dissect the transcriptional signature of developing eccrine glands, and they also uncover a unique dermal niche that is responsible for promoting eccrine gland developmental progression.
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Temporal regulation of vegetative phase change in plants Dev. Cell (IF 11.8) Pub Date : 2024-01-08 R. Scott Poethig, Jim Fouracre
During their vegetative growth, plants reiteratively produce leaves, buds, and internodes at the apical end of the shoot. The identity of these organs changes as the shoot develops. Some traits change gradually, but others change in a coordinated fashion, allowing shoot development to be divided into discrete juvenile and adult phases. The transition between these phases is called vegetative phase
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MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement Dev. Cell (IF 11.8) Pub Date : 2023-12-29 Michael V. Tran, Daria Khuntsariya, Richard D. Fetter, James W. Ferguson, Jennifer T. Wang, Alexandra F. Long, Lauren E. Cote, Stephen R. Wellard, Nabor Vázquez-Martínez, Maria D. Sallee, Mariya Genova, Maria M. Magiera, Sani Eskinazi, Jessica D. Lee, Nina Peel, Carsten Janke, Tim Stearns, Kang Shen, Zdenek Lansky, Jérémy Magescas, Jessica L. Feldman
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Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids Dev. Cell (IF 11.8) Pub Date : 2023-12-29 Sounak Sahu, Sarthak Sahoo, Teresa Sullivan, T. Norene O’Sullivan, Sevilay Turan, Mary E. Albaugh, Sandra Burkett, Bao Tran, David S. Salomon, Serguei V. Kozlov, Karl R. Koehler, Mohit Kumar Jolly, Shyam K. Sharan
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The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling Dev. Cell (IF 11.8) Pub Date : 2023-12-29 Claudia Carlantoni, Leon M.H. Liekfeld, Sandra A. Hemkemeyer, Danny Schreier, Ceren Saygi, Roberta Kurelic, Silvia Cardarelli, Joanna Kalucka, Christian Schulte, Manu Beerens, Reiner K. Mailer, Tilman E. Schäffer, Fabio Naro, Manuela Pellegrini, Viacheslav O. Nikolaev, Thomas Renné, Maike Frye
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Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens Dev. Cell (IF 11.8) Pub Date : 2023-12-27 Taciani de Almeida Magalhaes, Jingjing Liu, Charlene Chan, Kleiton Silva Borges, Jiuchun Zhang, Andrew J. Kane, Bradley M. Wierbowski, Yunhui Ge, Zhiwen Liu, Prabhath Mannam, Daniel Zeve, Ron Weiss, David T. Breault, Pengxiang Huang, Adrian Salic
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What approaches are needed to understand human development and disease? Dev. Cell (IF 11.8) Pub Date : 2023-12-18 Berna Sozen, Richard A. Flavell, Dudley W. Lamming, Debra L. Silver, Simona Parrinello, Cory Abate-Shen, Franziska Michor, Vijay G. Sankaran
Researchers are leveraging what we have learned from model organisms to understand if the same principles arise in human physiology, development, and disease. In this collection of Voices, we asked researchers from different fields to discuss what tools and insights they are using to answer fundamental questions in human biology.
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YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development Dev. Cell (IF 11.8) Pub Date : 2023-12-22 Joseph M. Collins, Annemarie Lang, Cristian Parisi, Yasaman Moharrer, Madhura P. Nijsure, Jong Hyun (Thomas) Kim, Saima Ahmed, Gregory L. Szeto, Ling Qin, Riccardo Gottardi, Nathaniel A. Dyment, Niamh C. Nowlan, Joel D. Boerckel
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Basal spot junctions of Drosophila epithelial tissues respond to morphogenetic forces and regulate Hippo signaling Dev. Cell (IF 11.8) Pub Date : 2023-12-21 Benjamin Kroeger, Samuel A. Manning, Yoshana Fonseka, Viola Oorschot, Simon A. Crawford, Georg Ramm, Kieran F. Harvey
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An essential signaling cascade for avian auditory hair cell regeneration Dev. Cell (IF 11.8) Pub Date : 2023-12-20 Nesrine Benkafadar, Mitsuo P. Sato, Angela H. Ling, Amanda Janesick, Mirko Scheibinger, Taha A. Jan, Stefan Heller
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Understanding the microenvironment and how this controls cell fate Dev. Cell (IF 11.8) Pub Date : 2023-12-18 Elaine Fuchs, Erik Sahai, Ashani T. Weeraratna, Benjamin Deneen, Carmen Chak-Lui Wong, András Simon
The microenvironment influences cell fate. In this collection of voices, researchers from the fields of cancer and regeneration highlight approaches to establish the importance of the microenvironment and discuss future directions to understand the complex interaction between cells and their surrounding environment and how this impacts on disease and regeneration.
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Human embryonic and fetal biobanking: Establishing the Dutch Fetal Biobank and a framework for standardization Dev. Cell (IF 11.8) Pub Date : 2023-12-18 Yousif Dawood, Marieke F.J. Buijtendijk, Doriane Bohly, Quinn D. Gunst, Daniel Docter, Eva Pajkrt, Roelof-Jan Oostra, Raoul C. Hennekam, Maurice J.B. van den Hoff, Bernadette S. de Bakker
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Shaping the brain: The emergence of cortical structure and folding Dev. Cell (IF 11.8) Pub Date : 2023-12-18 Shyam K. Akula, David Exposito-Alonso, Christopher A. Walsh
The cerebral cortex—the brain’s covering and largest region—has increased in size and complexity in humans and supports higher cognitive functions such as language and abstract thinking. There is a growing understanding of the human cerebral cortex, including the diversity and number of cell types that it contains, as well as of the developmental mechanisms that shape cortical structure and organization
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The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis Dev. Cell (IF 11.8) Pub Date : 2023-12-18 Isabella Burda, Adam C. Martin, Adrienne H.K. Roeder, Mary Ann Collins
The emergence of tissue form in multicellular organisms results from the complex interplay between genetics and physics. In both plants and animals, cells must act in concert to pattern their behaviors. Our understanding of the factors sculpting multicellular form has increased dramatically in the past few decades. From this work, common themes have emerged that connect plant and animal morphogenesis—an
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Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice Dev. Cell (IF 11.8) Pub Date : 2023-12-18 Maja C. Funk, Jan G. Gleixner, Florian Heigwer, Dominik Vonficht, Erica Valentini, Zeynep Aydin, Elena Tonin, Stefania Del Prete, Sylvia Mahara, Yannick Throm, Jenny Hetzer, Danijela Heide, Oliver Stegle, Duncan T. Odom, Angelika Feldmann, Simon Haas, Mathias Heikenwalder, Michael Boutros